CD28 Antibodies with Optimized CDRs for Detection

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Current anti-CD28 antibodies and associated methods are limited in their range of applications for detecting CD28 and diagnosing or treating CD28-related diseases or disorders.

Innovation Solution

Development of antibodies and antigen-binding fragments that specifically bind to CD28, including human CD28, with particular complementarity determining regions (CDRs) that enhance target specificity and application range.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If currently available anti-CD28 antibodies are used, then basic detection function is provided, but the range of applications is limited

Engineering Contradiction:

Improverange of applicationsVSAvoiddetection capability

Core Design Contradiction:

Adaptability or versatilityVSReliability

Solution Approach 1:

The patent applies parameter changes by modifying the complementarity determining regions (CDRs) of the antibody to achieve superior binding affinity and specificity for CD28. The optimized CDR sequences enable the antibody to maintain high detection capability while expanding applicability across diverse formats and conditions.

Inventive Principle:

Principle #35Parameter changes

2Measurement precision

If antibodies with enhanced specificity are developed, then detection precision is improved, but development complexity increases

Engineering Contradiction:

Improvedetection precisionVSAvoidantibody development complexity

Core Design Contradiction:

Measurement precisionVSDevice complexity

Solution Approach 1:

The patent applies local quality by focusing optimization efforts specifically on the complementarity determining regions (CDRs) of the antibody while maintaining the overall antibody structure. This targeted approach to modifying only the antigen-binding regions enables improved detection precision without requiring complete redesign of the entire antibody molecule.

Inventive Principle:

Principle #3Local quality

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The antibodies and antigen-binding fragments provide superior detection capabilities for CD28 and potential therapeutic benefits for CD28-related diseases or disorders, expanding the range of in vitro and in vivo applications.

Implementation Method 1

anti-CD28 antibodies and antigen binding fragments thereof that bind all or a portion of CD28

Methodology Applied

Scientific EffectAntigen-antibody binding:

Data Source

PatentUS20250052767A1CD28 binding antibodies and antigen binding fragments thereof

Publication Date: 2025.02.13 BIOLEGEND INC

AI summary

Compositions and methods comprising CD28 antibodies and antigen binding fragments thereof are provided.