Cell Surface Adhesion Compound for Improved Tissue Engraftment
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Solution Overview
Problem
Existing methods face challenges in transplanting cells into tissues and organs where direct cell transplantation or cell sheet transplantation is difficult, and achieving sufficient engraftment of cells.
Innovation Solution
A compound comprising a hydrophilic polymer, bile acid, and a protein-directed substance is adsorbed to cells to impart protein adhesion properties, enhancing their engraftment and viability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If direct cell transplantation or cell sheet transplantation is performed, then cell transplantation can be carried out, but the engraftment rate is low and insufficient quantity of cells can be established in the tissue or organ
Solution Approach 1:
The invention uses a composite compound comprising a hydrophilic polymer, bile acid, and protein-directed substance. This composite material imparts protein adhesion properties to cells, enabling them to adhere to extracellular matrix proteins in the transplanted tissue, thereby improving engraftment rate and establishing sufficient cell quantity.
Solution Approach 2:
The invention changes the surface properties of cells by adsorbing the compound, which alters the physical-chemical parameters of the cell surface. This enables cells that originally lacked protein adhesion properties to acquire the ability to bind to extracellular matrix proteins, directly improving engraftment efficiency.
2Reliability
If cells are transplanted alone, then transplantation can be performed, but the engraftment rate is low
Solution Approach 1:
The invention performs preliminary action by adsorbing the compound comprising hydrophilic polymer, bile acid, and protein-directed substance to cells before transplantation. This pre-treatment imparts protein adhesion properties to the cells, ensuring they can effectively engraft in the target tissue without requiring complex modifications during the transplantation process.
Solution Approach 2:
The compound acts as an intermediary between the transplanted cells and the host tissue environment. The protein-directed substance in the compound mediates the interaction between cell surface proteins and extracellular matrix proteins, facilitating successful engraftment while keeping the transplantation process relatively simple.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compound improves cell engraftment and maintains high viability even after cryopreservation, facilitating successful transplantation.
Implementation Method 1
a compound comprising a hydrophilic polymer or a derivative thereof, a bile acid or a derivative thereof, and a protein-directed substance; A method for producing cells having protein adhesion properties, comprising adsorbing the compound
Data Source
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AI summary
Provided are: a compound that imparts protein adhesion properties to cells; a method, using the compound, for producing cells having protein adhesion properties; cells adsorbed by the compound; and a cell sheet, a cell aggregation (spheroid, tumor-like body, etc.), an organoid, a three-dimensional tissue, etc. comprising the cells.