Cell Analysis Device Using Pre-stored Identifier Extraction

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Solution Overview

Problem

Current cell analysis technologies face challenges in achieving both high accuracy and high-speed cell separation, as accurate deep learning-based measurement information analysis is time-consuming, making fast and immediate cell separation difficult.

Innovation Solution

A cell analysis device and method that includes a determination target identifier extraction portion, an identifier acquisition portion, and a determination portion to quickly identify and separate cells based on optical identification of beads with imaging information, using a table correlating cell and identification substance information, allowing for immediate cell separation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If deep learning-based measurement information analysis is used to achieve high accuracy cell identification, then measurement precision is improved, but processing time increases making high-speed separation difficult

Engineering Contradiction:
Improvecell identification accuracyVSAvoidprocessing time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent applies preliminary action by pre-processing and storing measurement information in association with identification substance information before the actual cell separation process. The determination target identifier is extracted in advance from stored data, allowing the system to quickly retrieve pre-analyzed information during real-time operation without performing complex deep learning analysis at the moment of separation, thus resolving the contradiction between high accuracy and fast processing speed

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent extracts only the necessary determination target identifier information from the comprehensive measurement data stored in the storage unit. Instead of processing all measurement information in real-time, the system extracts specific identifier data that is sufficient for cell determination, reducing processing time while maintaining identification accuracy by using pre-stored analyzed data

Inventive Principle:
Principle #2Taking out (Extraction)

2Measurement precision

If comprehensive measurement information is collected for accurate cell analysis, then measurement precision is improved, but the amount of information to be processed increases reducing processing speed

Engineering Contradiction:
Improvecell analysis accuracyVSAvoidcell separation speed
Core Design Contradiction:
Measurement precisionVSProductivity

Solution Approach 1:

The patent extracts only the essential determination target identifier from comprehensive measurement information that has been pre-stored. By separating the identifier extraction from full measurement data processing, the system retrieves only the necessary information for cell determination, maintaining high accuracy through pre-collected comprehensive data while achieving fast processing by handling only extracted identifiers during separation

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The system performs comprehensive measurement information collection and analysis in advance, storing the results in association with identification substance information. This preliminary processing allows the system to have all necessary data prepared before separation, enabling quick retrieval and comparison during actual cell separation without the bottleneck of processing large amounts of data in real-time

Inventive Principle:
Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables quick and immediate cell separation by leveraging optical identification of beads within compartments, improving the speed and accuracy of cell analysis without destroying the cells.

Implementation Method 1

an identifier acquisition portion configured to acquire the identifier that is the information for identifying the identification substance included in the compartments flowing along the flow path

Methodology Applied
Scientific EffectOptical identification: Light

Data Source

PatentUS20230107603A1Cell analysis device, cell determination method, and program
Publication Date: 2023.04.06 THE UNIV OF TOKYO
  • US20230107603A1 patent drawing
  • US20230107603A1 patent drawing
  • US20230107603A1 patent drawing

AI summary

A cell analysis device includes a determination target identifier extraction portion configured to extract a determination target identifier that is information indicating an identification substance associated with a determination target cell that is a cell of a determination target from a table indicating a corresponding relationship between the cell and the identification substance for each compartment with respect to compartments flowing along a flow path including the cell and the identification substance that is a substance associated with the cell, an identifier acquisition portion configured to acquire the identifier that is the information for identifying the identification substance included in the compartments flowing along the flow path, a determination portion configured to determine a compartment including the determination target cell among the compartments flowing along the flow path on the basis of the identifier acquired by the identifier acquisition portion and the determination target identifier extracted by the determination target identifier extraction portion, and an output portion configured to output a determination result of the determination portion.