Cell Culture Bag Pressing Surface for Wrinkle-Free Liquid Thickness
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Solution Overview
Problem
Cell culture bags deform, leading to wrinkles that cause non-uniform liquid thickness and affect cell culture, and existing solutions like pressing between two members form wrinkles that hinder cultivation.
Innovation Solution
A cell culture jig with a mounting platform and pressing member that includes a slipping surface to reduce friction, allowing easy removal of wrinkles by oscillating the pressing member or using a sheet member with a slipping surface.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If the cell culture bag is pressed between two members to suppress liquid flow, then the stability of liquid contents is improved, but wrinkles form on the bag surface causing non-uniform liquid thickness
Solution Approach 1:
A sheet member is introduced as an intermediary between the pressing member and the cell culture bag. This sheet member has a pressing surface with a slipping surface that reduces friction, allowing the bag to be pressed without forming wrinkles. The sheet member mediates the interaction between the rigid pressing member and the flexible bag, enabling stable pressing while maintaining surface uniformity.
2Reliability
If the bag main body is made of flexible material for sealing, then the sealing performance is improved, but the bag deforms readily causing liquid flow and cell damage
Solution Approach 1:
The cell culture bag is preliminarily pressed between the mounting platform and the pressing member before cell culture begins. This preliminary pressing action stabilizes the bag's shape and prevents deformation during subsequent cell culture operations. The bag is held in a stable state by the pressing force, preventing liquid flow and cell damage while maintaining the flexibility needed for sealing.
3Stability of the object's composition
If a pressing member is used to hold the cell culture bag, then the position stability is improved, but friction causes wrinkles to form on the bag surface
Solution Approach 1:
The sheet member is designed with a slipping surface specifically at the contact area with the cell culture bag. This localized modification of the pressing surface reduces friction only where contact occurs, preventing wrinkles from forming. The rest of the pressing member maintains its pressing function, providing position stability without causing surface deformation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution effectively removes wrinkles on the cell culture bag surface, ensuring uniform liquid thickness and stable cell cultivation.
Implementation Method 1
A slipping surface configured to reduce a frictional force acting on a contact surface between the cell culture bag mounted on the mounting platform and a pressing surface of the pressing member
Data Source
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AI summary
A cell culture jig holds a cell culture bag. The cell culture jig includes a mounting platform on which the cell culture bag is mounted and a pressing member configured to press the cell culture bag mounted on the mounting platform. A slipping surface configured to reduce a frictional force acting on a contact surface between the cell culture bag mounted on the mounting platform and a pressing surface of the pressing member configured to press the cell culture bag.