Cell Carrier Particle Aggregates for Static-Free Aseptic Handling
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Solution Overview
Problem
Commercially available microcarriers in a powdery form are prone to static electricity, leading to spillage, loss, and environmental pollution, and are difficult to handle and store, necessitating a more manageable and stable form for cell culture applications.
Innovation Solution
Aggregating cell carrier particles into shaped forms such as tablets or blocks using methods like punch-forming, mold-forming, lyophilization, or dehydrating-evaporating processes to create stable aggregates that maintain porous connectivity and dispersibility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If cell carrier particles are used in a powdery form, then they are easy to package and transport, but they generate a large amount of static electricity causing spillage, loss, and environmental pollution
Solution Approach 1:
The patent combines multiple cell carrier particles into a single aggregate structure. This merging approach maintains the advantages of powdered form (easy packaging and transport) while eliminating the harmful static electricity effects by consolidating many small particles into one larger unit that can be handled as a single entity
2Duration of action of stationary object
If cell carrier particles are used in a powdery form, then they can be stored in packages, but they are prone to spillage and loss during use and weighing
Solution Approach 1:
By merging multiple particles into aggregates, the patent enables storage in packages while dramatically reducing spillage and loss during handling. The aggregated form allows for precise dosage control and easier transfer without the particles scattering or adhering to surfaces due to static electricity
3Ease of operation
If cell carrier particles are used in a powdery form, then they are available for use, but they require multiple measuring instruments and auxiliary tools making operations time-consuming
Solution Approach 1:
The patent combines multiple particles into pre-formed aggregates with known compositions. This eliminates the need for complex weighing and measuring operations, as the aggregates can be directly transferred and used, significantly reducing operation time while maintaining ease of use
4Object-generated harmful factors
If cell carrier particles are aggregated into shaped forms, then static electricity problems are reduced, but the particles need to maintain porous connectivity and dispersibility
Solution Approach 1:
The patent employs porous materials in the aggregate structure to maintain particle connectivity and dispersibility. The porous architecture allows individual particles within the aggregate to remain accessible and dispersible while the overall aggregate structure prevents static electricity issues associated with loose powdered forms
Solution Approach 2:
The patent uses composite material structures where cell carrier particles are combined in aggregate forms. This composite approach maintains the functional properties of individual particles (porosity, dispersibility) while achieving the handling advantages of aggregated structures (reduced static electricity, easier manipulation)
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The aggregates prevent static electricity, reduce loss, and facilitate aseptic operations by allowing easy packaging, sterilization, and quantitative use, maintaining particle properties for effective cell culture.
Implementation Method 1
The aggregate of cell carrier particles has an excellent rehydration property and a good dispersibility upon rehydration
Data Source
AI summary
The present disclosure discloses an aggregate of cell carrier particles and a method for preparing same. The aggregate of cell carrier particles is formed by aggregating cell carrier particles and has a particular shape including the shape of a tablet and the shape of a block. The method for preparing the aggregate of cell carrier particles is a punch-forming process, a mold-forming process, a lyophilization process or a dehydrating-evaporating process.