Cell Detaching Apparatus Ultrasonic Vibration Fluid Level Control
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Solution Overview
Problem
Conventional cell detaching apparatuses face issues with maintaining a constant vibration transmission fluid volume, leading to unstable vibration and temperature control, which affects cell quality and detachment efficiency.
Innovation Solution
A cell detaching apparatus that uses an acoustic matching liquid with a holding unit, a detaching unit for ultrasonic vibration, and a control unit to maintain a constant fluid level, incorporating a vibration tub and storage tub with fluid level indicators and a sinking weight to stabilize the vibration transmission fluid volume.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If ultrasonic wave is applied while supplying acoustic matching liquid, then cell detachment is achieved, but contact area between liquid and vessel changes causing vibration variation
Solution Approach 1:
The patent pre-establishes a fluid-tight connection between the ultrasonic emission unit and the processing target region before applying ultrasonic waves. This preliminary configuration ensures that the acoustic matching liquid maintains a constant contact area with the vessel throughout the cell detachment process, preventing vibration variations while achieving effective cell detachment.
2Reliability
If vessel is disposed on acoustic matching liquid, then contact area stability is improved, but liquid volume changes during ultrasonic vibration application
Solution Approach 1:
The patent incorporates a control unit that monitors the liquid volume in the holding unit and supplies additional acoustic matching liquid from the storage unit when the liquid level drops during ultrasonic vibration. This feedback mechanism maintains a constant liquid volume, ensuring stable contact area with the vessel while allowing continuous cell detachment operation.
3Device complexity
If fluid level is not controlled, then apparatus simplicity is maintained, but vibration transmission to cells becomes unstable
Solution Approach 1:
The patent employs a sinking weight mechanism that automatically adjusts the fluid level in the holding unit by sinking into the acoustic matching liquid. This self-service approach maintains optimal fluid level without requiring complex external control systems, achieving stable vibration transmission while keeping the apparatus structure relatively simple.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This configuration ensures consistent vibration and temperature control, improving cell quality and detachment efficiency while being cost-effective and environmentally friendly.
Implementation Method 1
a detaching unit configured to detach the cells from the base material by applying an ultrasonic vibration to the cells through the acoustic matching liquid
Implementation Method 2
an acoustic matching liquid with a holding unit, a detaching unit for ultrasonic vibration, and a control unit to maintain a constant fluid level
Data Source
AI summary
There is provided a cell detaching apparatus for detaching cells from a base material by applying an ultrasonic vibration via an acoustic matching liquid, with reduced variations of the vibration transmitted to the cells during application of the ultrasonic vibration. A cell detaching apparatus for detaching cells placed on a base material floating on an acoustic matching liquid, from the base material includes a holding unit configured to hold the acoustic matching liquid, a detaching unit configured to detach the cells from the base material by applying an ultrasonic vibration to the cells through the acoustic matching liquid, and a control unit configured to perform control to maintain a constant height of a fluid level of the acoustic matching liquid held by the holding unit with respect to the base material.