Cell Impedance Analysis via Electromagnetic Radiation
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Solution Overview
Problem
Conventional methods for cell analysis, such as flow cytometry, face challenges related to fluidic mechanics, limiting throughput and efficiency in cell identification and counting.
Innovation Solution
A device and method for analyzing biological cells using electromagnetic radiation, where a head provides electromagnetic radiation to a subset of cells on a platter, and an electrode detects the radiation to determine impedance values, facilitating cell identification and counting.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If conventional flow cytometry methods are used for cell analysis, then cell identification and counting can be performed, but throughput is limited due to fluidic mechanics challenges
Solution Approach 1:
The patent replaces the mechanical fluidic system with an electromagnetic field-based system. Instead of using fluid flow to transport and analyze cells, the invention uses electromagnetic radiation to interact with cells positioned on a platter, eliminating the complexity of fluidic mechanics while maintaining cell analysis capability and significantly improving throughput.
Solution Approach 2:
The invention divides the cell analysis system into discrete components: a platter for positioning cells, a head for providing electromagnetic radiation, and an electrode for detection. This segmentation allows for simplified, independent optimization of each component and enables high-throughput analysis without the bottlenecks of integrated fluidic systems.
2Productivity
If electromagnetic radiation method is used for cell analysis, then throughput and efficiency are improved, but device complexity increases
Solution Approach 1:
The electromagnetic radiation head and electrode system serves multiple functions: it provides radiation, detects interaction, and determines impedance values. This multi-functionality reduces the need for separate specialized components, thereby managing device complexity while achieving high throughput.
Solution Approach 2:
The system utilizes changes in electromagnetic radiation parameters (frequency, intensity, phase) as cells interact with the radiation. By measuring impedance changes through these parameter variations, the system achieves high-throughput analysis with relatively simple detection electronics, avoiding the need for complex mechanical or fluidic control systems.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method enables accurate and efficient determination of impedance values for biological cells, improving cell identification and counting processes, and potentially replacing or complementing conventional methods.
Implementation Method 1
a first head positioned adjacently to the first platter for providing first electromagnetic radiation to at least a first subset of the first group of biological cells; and a first electrode positioned adjacently to the first platter for detecting the first electromagnetic having interacted with the first subset of the first group of biological cells
Implementation Method 2
determining impedance values for the first subset of the first group of biological cells based on the first electromagnetic radiation detected by the first electrode
Data Source
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AI summary
A device for analyzing biological cells is disclosed. The device includes a first platter (102) for positioning a first group of biological cells (180); a first head (104) positioned adjacently to the first platter (102) for providing first electromagnetic radiation to at least a first subset of the first group of biological cells (180); and a first electrode (106) positioned adjacently to the first platter (102) for detecting the first electromagnetic having interacted with the first subset of the first group of biological cells (180) for determining impedance values for the first subset of the first group of biological cells.