Cell Injection Needle with Priming Portion for Tissue Integration
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Solution Overview
Problem
Current cell delivery methods often result in cells failing to integrate into recipient tissue, as they are delivered in isolated pockets with limited contact, and many cells struggle to find suitable integration sites, leading to inefficiency in providing therapeutic functions.
Innovation Solution
A cell delivery system comprising a surgical needle with a priming portion and a cell-carrying portion, where the needle is configured to transition from an insertion position to a delivery position, allowing for tissue priming and effective cell placement by promoting a healing or regeneration response in the tissue, using a syringe and hollow needle to facilitate cell delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If cells are delivered using conventional injection methods, then cells can be introduced into the body, but the cells fail to integrate into recipient tissue effectively
Solution Approach 1:
The needle performs a priming action at the target site before cell delivery, preparing the tissue by creating a receptive environment that promotes cell integration. This preliminary tissue preparation ensures that when cells are subsequently delivered, they can effectively integrate and perform their therapeutic function, resolving the contradiction between integration success and therapeutic efficiency.
2Quantity of substance
If excess cells are injected to compensate for poor integration, then more cells are available for potential integration, but the majority of cells still fail to integrate or find suitable locations
Solution Approach 1:
By performing preliminary priming of the target tissue before cell injection, the system creates an optimal reception environment that significantly improves cell integration rates. This eliminates the need to inject excess cells, as the primed tissue ensures high integration success for the delivered cell population, thereby reducing waste and improving overall efficiency.
3Ease of operation
If cells are delivered in tiny pockets or pools, then cells can be contained during delivery, but many cells have no contact with surrounding tissue
Solution Approach 1:
The priming portion of the needle prepares the target tissue by creating a receptive site with increased surface area and enhanced cellular activity before cell delivery. This preliminary action ensures that when cells are released from the needle, they are immediately in contact with primed tissue, eliminating the problem of cells being trapped in isolated pools without tissue contact.
Data Source
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AI summary
Methods and apparatus are provided for treating tissue with apparatus that includes an priming portion for initiating a healing response in the tissue to be treated, and which delivers a bioactive agent during or after preparing tissue adjacent the apparatus, as by generating or aiding a healing, regeneration or repair response in the tissue. The priming portion may comprise an abrasive surface, fluid ejection ports, and/or stimulation by electrical, thermal, or light energy.