Cell Membrane Coating for Cross-Species Delivery by Membrane Fusion
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Solution Overview
Problem
Existing technologies lack effective methods for delivering cross-species cell components intracellularly while shielding immunogenicity, as they primarily focus on drug loading and deimmunization without considering cross-species component delivery.
Innovation Solution
A cell membrane-based biological material is developed, composed of a target cell membrane encapsulating a cross-species cell component, utilizing membrane fusion for stable intracellular delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If cell membrane coating is used for drug loading and deimmunization, then biocompatibility and circulation time are improved, but the method is limited to drug delivery and does not enable cross-species cell component delivery
Solution Approach 1:
The cell membrane coating is designed to perform multiple functions: it provides immunogenicity shielding for drugs while simultaneously enabling the delivery of cross-species cell components through membrane fusion. The same cell membrane structure that protects drugs now also facilitates the delivery of foreign cell components by serving as a fusion-compatible carrier.
Solution Approach 2:
The cell membrane coating encapsulates cross-species cell components within its structure, creating a nested configuration where the foreign component is contained within the protective membrane shell. This nested structure allows the component to be delivered without direct exposure to the immune system while maintaining delivery capability.
2Object-affected harmful factors
If cell membrane is used for drug encapsulation, then immune shielding is improved, but intracellular delivery capability is insufficient
Solution Approach 1:
The cell membrane coating acts as an intermediary between the cross-species cell component and the target cell. It provides immune shielding during circulation while its membrane fusion properties enable it to mediate the transfer of the encapsulated component into the target cell's interior, bridging the gap between protection and delivery.
Solution Approach 2:
The cell membrane's physical and chemical parameters are optimized to balance two opposing requirements: sufficient stability to provide immune shielding during circulation, and sufficient fusogenicity to enable membrane fusion with target cells for intracellular delivery. This parameter optimization allows the membrane to transition between protective and delivery modes.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The material achieves high selectivity, low off-target rates, and lysosome escape, enabling the cross-species component to stably function in the target cell cytoplasm.
Implementation Method 1
utilizing membrane fusion for stable intracellular delivery
Data Source
AI summary
Disclosed are a cell membrane-based biological material for cross-species cell component delivery and a preparation method thereof. The biological material is based on cell membrane coating, and a cross-species cell component is delivered into a specific cell in a membrane fusion mode, so that the cross-species component stably plays a specific function, thus providing a new thought and strategy for intracellular delivery of cross-species immunogenic biological materials.