Pre-Filled Cell Processing Plate With Easy-Peel Sealing
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Solution Overview
Problem
Existing biological cell processing solutions require preparation of biological cell processing solutions by operators, which is time-consuming, and the sealing materials are difficult to peel off, hindering quick start of operations.
Innovation Solution
A plate for biological cell processing with pre-filled recesses of biological cell processing solutions and peelable sealing sheets, allowing quick setup and easy opening without leakage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If biological cell processing solutions are prepared manually by operators, then the processing can be customized, but the preparation time is excessive and productivity is reduced
Solution Approach 1:
The biological cell processing solutions are pre-filled into the recesses of the plate before use. This preliminary action eliminates the need for operators to manually prepare solutions during the processing operation, thereby reducing preparation time and increasing productivity. The solutions are prepared in advance and stored in the plate's recesses, ready for immediate use.
2Reliability
If sealing materials are used to seal the recesses, then the solutions are protected from contamination, but the sealing materials are difficult to peel off and operation becomes complex
Solution Approach 1:
The sealing sheet has different local properties: the main body portion provides strong sealing when pressed against the recess openings, while the peeled portion has reduced adhesion to allow easy removal. This local differentiation of sealing strength enables both effective sealing during storage and easy peeling during operation.
Solution Approach 2:
The sealing sheet transitions from a sealed state to a peeled state dynamically. When the lid is removed, the sealing sheet can be peeled off from the recess openings. The sealing sheet maintains its sealing function when needed and can be easily removed when not needed, providing dynamic adaptability.
3Reliability
If the sealing sheet is pressed firmly to ensure leak-proof sealing, then sealing reliability is improved, but the peeling process becomes more difficult
Solution Approach 1:
The sealing sheet has differentiated local properties where the main body provides strong sealing pressure for leak-proof sealing, while the peeled portion has reduced adhesion for easy removal. This local quality differentiation resolves the contradiction between firm pressing for sealing and easy peeling for operation.
Data Source
Figure 1
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Figure 4~5
AI summary
A plate for biological cell processing operation 1a has a plate body 2a and a lid 3a. The plate body has an upper surface portion 52a, a base portion 5a, an annular wall portion 6a extending above the base portion 5a, a recess 8 inside the annular wall portion 6a, cell processing solution in the recess, and a sealing sheet 4 sealing the recess. The lid covers the annular wall portion and recess of the plate and is placed over the base portion. The sealing sheet 4 has a sheet body portion 41 sealing the recess and a gripping portion for peeling 42. In the lid attached state, the gripping portion for peeling passes between the annular wall portion and the lid and is close to an upper surface portion 52a of the base portion, while in the lid unattached state, the gripping portion for peeling rises up and away from the upper surface portion 52a.