Multi-Component Cell-Protective Composition for Oxidative Stress
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Solution Overview
Problem
Declining DNA protection and repair mechanisms in cells contribute to genomic instability, which underlies various age-related diseases such as cancer, and are associated with the decline in cell and tissue function with aging.
Innovation Solution
A composition comprising a combination of active components like acacetin, ACTI peptide, alpha-lipolic acid, and others, administered orally or topically, enhances cell resistance to DNA damage, oxidative stress, and mitochondrial dysfunction, and improves DNA repair capacity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional single-component antioxidants are used to protect cells from oxidative stress, then some protective effect is achieved, but the protection is insufficient against multiple types of cellular damage including DNA damage and mitochondrial dysfunction
Solution Approach 1:
The patent combines multiple antioxidant components with different mechanisms of action into a single composition. This includes antioxidants that scavenge different types of reactive oxygen species, components that protect DNA directly, and agents that support mitochondrial function. The synergistic combination provides comprehensive protection against multiple types of cellular damage that single components cannot achieve alone.
Solution Approach 2:
The composition is designed to perform multiple protective functions simultaneously: scavenging reactive oxygen species, protecting DNA from oxidative damage, supporting mitochondrial function, and enhancing cellular repair mechanisms. This multi-functional approach allows a single composition to address various aspects of oxidative stress and cellular aging concurrently.
2Reliability
If high doses of single antioxidants are administered to achieve sufficient protection, then protective effect increases, but toxicity and side effects increase
Solution Approach 1:
By combining multiple antioxidants with different mechanisms and targets, the patent achieves synergistic protection where lower doses of each individual component can provide the same or greater protective effect than high doses of a single antioxidant. This reduces the risk of toxicity associated with high-dose single antioxidant administration.
Solution Approach 2:
The composition includes components that work through different pathways and mechanisms, acting as intermediaries that collectively achieve protection without requiring high concentrations of any single agent. This distributed approach to protection minimizes the harmful effects associated with high doses of individual antioxidants.
Data Source
AI summary
There are described compositions comprising an effective amount of a combination of two or more components, said components selected from acacetin, ACTI peptide, alpha-lipolic acid, alprostadil, anisomycin, apigenin, ascorbic acid, astragalus, berberine, β-lapachone, β-hydroxy-beta-methyl-butyrate, Bacopa monnieri, catechin, catechol, chamomile, chrysin, coumestrol, curcumin, dinitrophenol, dinoprost, ellagic acid, (−)-epigallocatechin gallate, green tea extract, fisetin, genistein, ginsenoside RE, glabridin, 18-α-glycyrrhetinic acid, 18-β-glycyrrhetinic acid, glycyrrhizin, hydroquinone, isoquercitrin (EMIQ), kaempferol, kuromanin, leucine, lithium, luteolin, luteolin, luteolinidin, melatonin, menadione, 1-methylnicotinamide (MNA), methyl salicylate, myricetin, nadide, niacin (vitamin B3), nicotinamide (NAM), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), nicotinic acid adenine dinucleotide (NaAD), nicotinic acid mononucleotide (NaMN), parsley (Petroselinium crispum), phenylephrine, pokeweed mitogen, 15-Δ prostaglandin J2, puromycin, quercetin, quinolinic acid, retinoic acid, trichostatin A, troxrutin, rutin, tryptophan, vitamin D3, withaferin A, wortmannin and zinc (including salts thereof).