Automated Allogeneic Cell Selection System
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current systems for selecting and distributing umbilical cord blood preparations for transplantation lack automation, leading to time-consuming and error-prone processes, especially in matching HLA compatibility and cell count correlations, and do not efficiently handle multiple transplantation scenarios.
Innovation Solution
A system that processes patient data against registered cell preparations using a multi-level compatibility matrix, providing automatic search and selection of suitable umbilical cord blood preparations based on HLA match, cell count, and other criteria, with decentralized inventory management and automated workflow support for clinics and blood banks.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If manual selection process is used by coordinators to match HLA compatibility and cell count, then flexibility in decision-making is maintained, but the process becomes time-consuming and error-prone
Solution Approach 1:
The patent replaces the manual mechanical selection process with an automated computer-based system that uses algorithms to match HLA compatibility and cell count requirements. The system automatically retrieves patient data, compares it against stored preparations in databases, and generates match recommendations, eliminating manual data entry and comparison errors while significantly reducing selection time.
Solution Approach 2:
The system enables self-service by allowing the automated algorithm to independently perform the matching process without requiring coordinator intervention for data retrieval and comparison. The system automatically queries databases, processes compatibility criteria, and generates results, freeing coordinators to focus only on final clinical decision-making.
2Adaptability or versatility
If decentralized inventory management is implemented across multiple banks, then availability of suitable preparations increases, but data standardization and correlation become more difficult
Solution Approach 1:
The patent implements a universal data standard that enables multiple decentralized banks to participate in the system. The standardized data structure allows the same software platform to query and compare preparations from different banks uniformly, providing multi-bank access through a single interface while maintaining each bank's operational independence.
Solution Approach 2:
The system introduces a centralized data exchange platform as an intermediary between decentralized banks and the matching algorithm. This intermediary layer handles data standardization, validation, and correlation, allowing banks to maintain their own inventory systems while enabling seamless integration through common data protocols and formats.
3Measurement precision
If iterative manual process is used for coordinator selection, then thorough evaluation is possible, but the process is susceptible to errors and delays
Solution Approach 1:
The patent replaces the iterative manual evaluation process with an automated computer-based system that consistently applies predefined matching criteria. The algorithm systematically compares patient requirements against all available preparations using standardized algorithms, eliminating human errors in data entry and comparison while maintaining thorough evaluation through comprehensive database queries.
Solution Approach 2:
The system implements automated feedback loops where the algorithm continuously refines match recommendations based on comparison results. The system provides feedback to coordinators about match quality, cell count adequacy, and HLA compatibility, allowing coordinators to review only the most promising options while the system handles the exhaustive evaluation of all possibilities.
Data Source
AI summary
The invention relates to a system for the automatic, rapid and dynamic conveyance of biological cells for transplant, therapy or research purposes between withdrawalcentres or banks (storage facilities) and clinics, transplant centres or research facilities and also for the monitaring and backing of the processes from request transmission, for supply of a cell specimen which is suitable for the allogeneic transplant, through application of the conveyed specimens to tracking of the results in a patient and the provision of these data for statistical and other purposes. For the first time, the system is able to put forward complete solution proposals for specifically stored transplants online and automatically.