Cell Sensor Partition Board Surface Carbon Control
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Solution Overview
Problem
Existing cell electro-physiological sensors lack an optimal structure for the planar substrate, including shape and surface condition, which affects the holding properties of cells, leading to inefficiencies in measuring cellular potentials with high background noise.
Innovation Solution
A cell electro-physiological sensor with a partition board having through-holes and specific surface modifications, including an atomic ratio of carbon not greater than 15 atomic percent and enhanced hydrophilicity, to securely hold cells and reduce background noise during potential measurements.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional planar substrates are used for cell holding, then cell measurement can be performed, but background noise is high and cell holding is insufficient
Solution Approach 1:
The patent applies parameter changes by modifying the surface chemical composition of the planar substrate. Specifically, it controls the atomic ratio of carbon at the surface to be not greater than 15 atomic percent, which fundamentally changes the surface properties from hydrophobic to hydrophilic. This parameter change reduces background noise and improves cell holding capability, thereby enhancing measurement precision.
2Device complexity
If conventional planar substrates are used, then device structure is simple, but cell holding properties are insufficient
Solution Approach 1:
The patent maintains device simplicity while improving cell holding reliability through parameter changes in surface composition. By controlling the carbon atomic ratio to ≤15%, the surface becomes naturally more hydrophilic, providing better cell adhesion without adding complex structural elements. This achieves improved reliability while preserving the simplicity of the planar substrate design.
3Stability of the object's composition
If surface carbon content is high, then substrate stability is maintained, but cell holding and noise reduction are compromised
Solution Approach 1:
The patent applies local quality by differentiating between bulk material properties and surface properties. The bulk substrate maintains its original stable composition, while only the surface layer (where cells contact) is modified to have low carbon content (≤15 atomic ratio). This localized modification improves cell holding and measurement precision without compromising overall substrate stability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The sensor effectively measures cellular potentials with reduced background noise and improved cell holding, allowing for efficient and accurate recording of cellular phenomena.
Implementation Method 1
The atomic ratio of carbon at the first surface of the partition board is not greater than 15 atomic percent of the composition of the first surface of the partition board
Implementation Method 2
the cells are automatically pulled and easily held by a suction force from a back surface of the substrate
Data Source
AI summary
A cell electro-physiological sensor includes a sensor chip including a partition board having a first surface and a second surface opposite to the first surface, a member for forming a first region provided on the first surface of the partition board, and a member for forming a second region provided on the second surface of the partition board. The partition board has a through-hole provided therein, the through-hole having a first opening which opens to the first surface, a second opening which opens to the second surface, and a wall. The first region contacts the first opening of the through-hole. The first region is arranged to contain cell suspension. The atomic ratio of carbon at the first surface of the partition board is not greater than 15 atomic percent of the composition of the first surface. The cell electro-physiological sensor causes the cell to be tightly held at the first opening of the through-hole in the partition board, thereby measuring a potential of the cell efficiently.