Cell Separation Chip Cartridge Base Plate Integration
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Solution Overview
Problem
Current cancer cell separation systems face challenges in achieving high accuracy due to contamination and inconsistent flow rates during blood sample injection, and they are often expensive and complex to install and maintain.
Innovation Solution
A cell separation system with a cartridge and base plate design where the injection and separation parts are integrated on the same cartridge, allowing for easy coupling and decoupling, and featuring a separation chip with specific channel structures and magnetic chip for accurate cancer cell capture, along with liquid sensors and valves for flow control.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If cancer cell separation systems use disposable components and complex installation procedures, then contamination during injection is reduced, but the system becomes expensive and difficult to maintain
Solution Approach 1:
The system is divided into separate modules: a disposable cartridge containing the injection part and separation part, and a reusable base plate. This segmentation allows the cartridge to be easily replaced without complex installation procedures, reducing both contamination risk and maintenance complexity.
Solution Approach 2:
The injection part and separation part are integrated into a disposable cartridge that is discarded after use. This eliminates the need for complex cleaning and maintenance procedures while ensuring consistent performance and minimizing contamination risks associated with reusable components.
2Manufacturing precision
If cancer cell separation systems use integrated cartridge design with injection and separation parts, then coupling accuracy is improved, but the device structure becomes more complex
Solution Approach 1:
The injection part and separation part are merged into a single integrated cartridge assembly. This integration ensures precise alignment and coupling between components while maintaining a relatively simple overall device structure through modular design.
3Measurement precision
If magnetic material is used as carrier for cancer cell separation, then separation accuracy is improved, but the system becomes more expensive
Solution Approach 1:
The magnetic material is integrated into a disposable cartridge that can be mass-produced at low cost. This approach provides high separation accuracy through magnetic carrier particles while keeping the overall system cost-effective by using the expensive magnetic material only in the disposable portion.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This design enhances the accuracy and efficiency of cancer cell separation, reduces costs by allowing for easy replacement and reuse of components, and simplifies the installation process while maintaining consistent flow rates and minimizing contamination.
Implementation Method 1
a magnetic chip for cancer cell capture
Data Source
AI summary
The present invention relates to a system and method for cell separation. The system includes: a cartridge having a polygonal shape in cross section and including an injection part, a separation chip separating a flow channel of a sample injected through the injection part, and a discharge part; and a base plate coupled to the cartridge through its upper surface and including a magnetic chip for cancer cell capture, liquid sensors, and valves. The method includes: coupling a cut plane of one side of the cell separation cartridge to one side of the base plate; engaging a recess formed at the other end of the cell separation cartridge with a pin formed at the other end of the base plate; fixing holes of the separation chip of the cell separation cartridge and holes of the magnetic chip of the base plate using a fixing member to match the holes of the separation chip of the cell separation cartridge and the holes of the magnetic chip of the base plate; and determining whether a pattern of the separation chip of the cell separation cartridge matches a pattern of the magnetic chip of the base plate.