Cell Sheet Detachment Alignment to Reduce Tearing
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Solution Overview
Problem
Existing methods for detaching cell sheets from culture containers often result in tearing due to mismatched directions of impact and container movement, leading to inefficiencies and damage.
Innovation Solution
A cell detachment system and method that adjusts the direction of shaking parallel to the detachment direction of the cell sheet, using a shaking unit and setting unit to maintain alignment, combined with techniques like tapping, water flow, and ultrasonic vibrations to facilitate detachment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If the container holder is allowed to collide with a collision target member to detach cell sheets, then detachment efficiency is improved, but cell sheets are prone to tearing
Solution Approach 1:
The patent applies dynamics by making the shaking direction adjustable and adaptable during the detachment process. The shaking direction is changed based on the detachment progressing direction detected by the information acquisition unit, allowing the system to dynamically optimize the detachment process while preventing cell sheet tearing
Solution Approach 2:
The patent implements feedback by using the information acquisition unit to detect the detachment progressing direction and then adjusting the shaking direction accordingly. This closed-loop control ensures that the shaking direction remains substantially parallel to the detachment progressing direction, improving detachment efficiency while preventing cell sheet damage
2Productivity
If the shaking direction is not aligned with the detachment progressing direction, then the detachment process is simpler, but detachment efficiency decreases and cell sheets may tear
Solution Approach 1:
The system dynamically adjusts the shaking direction based on real-time detection of the detachment progressing direction. This dynamic adaptation optimizes detachment efficiency while the control unit manages the complexity through automated direction adjustment
Solution Approach 2:
The information acquisition unit provides feedback on the detachment progressing direction, which the control unit uses to adjust the shaking direction. This feedback mechanism improves detachment efficiency while the automated control system manages the operational complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Efficient detachment of cell sheets with reduced tearing by aligning shaking direction with detachment progress, enhancing detachment efficiency and cell survival.
Implementation Method 1
a shaking unit that shakes the culture container; and a setting unit that sets, on a basis of the information regarding the detachment progressing direction, the detachment progressing direction and a direction of the shaking to be substantially parallel to each other
Implementation Method 2
a detachment start unit that starts detachment of the cell sheet
Data Source
AI summary
A cell detachment system that detaches a cell sheet adhering to a culture container from the culture container includes a detachment start unit that starts detachment of the cell sheet; an information acquisition unit that acquires information regarding a detachment progressing direction of the cell sheet after start of the detachment of the cell sheet; a shaking unit that shakes the culture container; and a setting unit that sets, on a basis of the information regarding the detachment progressing direction, the detachment progressing direction and a direction of the shaking to be substantially parallel to each other.