Cell Sheet Detachment With Direction-Aligned Shaking

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Solution Overview

Problem

Existing methods for detaching cell sheets from culture substrates often result in tearing due to mismatched directions of impact and detachment, leading to inefficiencies and damage.

Innovation Solution

A cell detachment system that generates a liquid flow parallel to the detachment direction, using shaking mechanisms and ultrasonic vibrations to promote detachment while minimizing tearing, and includes a setting unit to align the shaking direction with the detachment progression.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If back-and-forth movement is applied to detach cell sheets, then detachment efficiency is improved, but cell sheets may tear if the impact direction does not match the detachment direction

Engineering Contradiction:

Improvedetachment efficiencyVSAvoidcell sheet integrity

Core Design Contradiction:

ProductivityVSReliability

Solution Approach 1:

The system dynamically adjusts the shaking direction to match the detachment progression direction. The control unit monitors how the cell sheet detaches and automatically changes the shaking direction in real-time, transforming a static impact approach into a dynamic adaptive process that maintains both efficiency and integrity

Inventive Principle:

Principle #15Dynamics

Solution Approach 2:

The system incorporates feedback mechanisms where the control unit detects the detachment progression and uses this information to adjust subsequent shaking directions. This closed-loop control ensures that each impact is optimally directed to continue detachment without causing tears

Inventive Principle:

Principle #23Feedback

2Speed

If high-speed impact is applied to improve detachment speed, then productivity increases, but the risk of tearing increases if direction is not aligned

Engineering Contradiction:

Improvedetachment speedVSAvoidtearing damage

Core Design Contradiction:

SpeedVSObject-affected harmful factors

Solution Approach 1:

The system applies asymmetric shaking patterns where the direction and intensity of impacts are varied based on the specific detachment needs. Rather than uniform symmetric impacts, the shaking is tailored to match the asymmetric progression of cell sheet detachment, maximizing speed while minimizing damage

Inventive Principle:

Principle #4Asymmetry

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Efficient detachment of cell sheets with reduced tearing by aligning the shaking direction with the detachment direction, enhancing the detachment process and maintaining cell integrity.

Implementation Method 1

shaking mechanisms and ultrasonic vibrations to promote detachment

Methodology Applied

Scientific EffectMechanical shaking: Shaking

Implementation Method 2

shaking mechanisms and ultrasonic vibrations to promote detachment

Methodology Applied

Scientific EffectUltrasonic vibrations: Ultrasonic Vibration

Data Source

PatentEP4617351A1Cell detachment system and cell detachment method

Publication Date: 2025.09.17 CANON KK

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AI summary

A cell detachment system that detaches a cell sheet adhering to a culture container (8) from the culture container (8) includes a detachment start unit that starts detachment of the cell sheet; an information acquisition unit that acquires information regarding a detachment progressing direction of the cell sheet after start of the detachment of the cell sheet; a shaking unit (3) that shakes the culture container (8); and a setting unit that sets, on a basis of the information regarding the detachment progressing direction, the detachment progressing direction and a direction of the shaking to be substantially parallel to each other.