Cell Sheet Forming Package With Magnetic Sliding Cover
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Solution Overview
Problem
Current methods for producing cell and tissue sheets are time-consuming and expensive, requiring laboratory facilities and are prone to damage or contamination during transportation due to inadequate environmental control.
Innovation Solution
A cell and tissue sheet forming package and associated cell injection equipment that allows on-site production of cell sheets using a container body with a hydrophilic membrane and sliding door plate, combined with a cell injection equipment featuring a carrier, heating elements, and magnetic assemblies for controlled injection and thermal processing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If cell culture is performed using traditional laboratory procedures, then cell sheets can be produced, but the process becomes extremely time-consuming and expensive
Solution Approach 1:
The patent applies preliminary action by pre-preparing the container body with membrane, sliding door plate, and sealing film before cell injection. The container is pre-assembled with all necessary components (cavity, membrane support structure, magnetic assemblies) so that cell sheets can be rapidly formed immediately after cell injection without requiring lengthy laboratory culture procedures. This pre-positioning of components enables the cell formation process to begin instantly, dramatically reducing the time loss associated with traditional cell culture setup and preparation.
2Ease of operation
If cells are transported without proper environmental control, then transportation becomes simpler, but the risk of damage or contamination increases
Solution Approach 1:
The patent creates a controlled inert environment within the sealed container body that protects cells during transportation. The container is hermetically sealed with a sealing film that covers the sliding door plate and container body, establishing a stable internal environment that isolates cells from external contaminants and environmental fluctuations. This sealed inert atmosphere maintains cell integrity without requiring complex active environmental control systems during transport, thus achieving both simplicity and reliability.
Solution Approach 2:
The patent applies beforehand cushioning by designing the container body with a cavity that provides protective spacing and cushioning for the membrane and cell solution. The structural design includes walls and partitions that cushion and protect the delicate cell-containing membrane from physical damage during transportation, preventing cell rupture or contamination before the damage can occur.
3Reliability
If a sealed container is used to protect cells, then contamination is prevented, but the ability to inject solution and monitor cell formation is reduced
Solution Approach 1:
The patent applies dynamics by incorporating a sliding door plate that can move between positions to expose or cover the cavity and membrane. The sliding door plate transitions from a closed sealed position (protecting cells) to an open exposed position (allowing injection and monitoring). This dynamic mechanism maintains the sealed protective environment while enabling operational access when needed, resolving the contradiction between protection and accessibility.
Solution Approach 2:
The patent uses the sliding door plate as an intermediary mechanism between the sealed container environment and the external injection/monitoring operations. The door plate acts as a mediator that can be moved to allow solution injection through the hole and to enable optical monitoring of cell formation on the membrane, while maintaining the overall sealed protective environment of the container body during non-operational periods.
4Ease of operation
If magnetic assemblies are used to slide the door plate, then precise control is achieved, but the device complexity increases
Solution Approach 1:
The patent applies mechanics substitution by replacing complex mechanical driving mechanisms with a magnetic field-based control system. The passive magnetic assembly on the sliding door plate interacts with an external positive magnetic assembly to achieve precise sliding control without mechanical connections, gears, or motors inside the sealed container. This substitution of mechanical systems with magnetic field interaction simplifies the internal device structure while maintaining precise control capability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Simplifies cell therapy procedures by eliminating the need for laboratory culturing and reduces the risk of temperature-related damage during transportation, enabling efficient on-site production and application of cell sheets.
Implementation Method 1
a passive magnetic assembly, disposed at the sliding door plate for connecting magnetically a positive magnetic assembly
Implementation Method 2
at least one heating element, disposed at the base block for providing thermal energy to the membrane and the solution
Implementation Method 3
a membrane, disposed in the cavity, made of a hydrophilic material
Data Source
Figure 1
Figure 2
Figure 3~3A
AI summary
A cell and tissue sheet forming package (100) includes a container body (10), a membrane (20), a sliding door plate (30) and a sealing film (40). The sliding door plate (30) is disposed horizontally and slidably on a top of the container body (10) so as to cover or expose the membrane (20). The sliding door plate (30) has a hole (31) and a passive magnetic assembly (32). The cell injection equipment (200) includes a carrier (50), an injection mechanism (60) and a drive mechanism. The carrier (50) is to carry the cell and tissue sheet forming package (100), and the drive mechanism is to move the carrier (50) and the injection mechanism (60) so as to have the injection mechanism (60) to inject a solution (SL), through the hole (31), into the cell and tissue sheet forming package (100). A heating element (53) of the carrier (50) is introduced to heat the membrane (20) and the solution (SL) so as to transform the solution (SL) into a colloid sheet on the membrane for being treated as a cell and tissue sheet. Then, the positive magnetic assembly (54) engages magnetically the passive magnetic assembly (32) to slide the sliding door plate (30) to expose the cell and tissue sheet.