Cell Suction System with Optical Detection for Micron-Order Precision

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Solution Overview

Problem

Current methods for suctioning intracellular substances are inefficient due to the need for manual visualization of the suction tip, resulting in low positional precision and reduced ability to process multiple cells effectively.

Innovation Solution

A cell suction system with a tubular tip, detection section for precise positioning using optical input/output units and signal-processing units, and a conveyance section for three-dimensional movement of the suction tip, allowing for micron-order precision in guiding the tip to a specific cell without relying on manual viewing.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If manual visualization of the suction tip is used, then the system is simple to operate, but the positional precision is low and processing efficiency is reduced

Engineering Contradiction:
Improvepositional precisionVSAvoidsystem complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent replaces manual visual observation with an optical detection system that uses a microscope and camera to automatically detect the position of the suction tip front end. This substitution of mechanical/visual methods with optical detection systems enables precise automated positioning while maintaining operational simplicity through computer control.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent introduces an optical intermediary system (microscope and camera) that acts as a mediator between the suction tip and the control system. This intermediary captures optical images of the suction tip position and transmits this information to the computer, enabling precise positioning without direct manual visualization.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Productivity

If manual cell-by-cell analysis is performed, then each cell can be carefully examined, but the processing speed is slow and productivity is low

Engineering Contradiction:
Improveprocessing efficiencyVSAvoidtime for cell analysis
Core Design Contradiction:
ProductivityVSLoss of time

Solution Approach 1:

The system enables self-service operation where the computer automatically controls the suction section positioning based on detection section feedback. The operator simply needs to initiate the process, and the system autonomously performs the repetitive tasks of positioning and suction, dramatically improving productivity while reducing manual time investment.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The patent implements a feedback control loop where the detection section continuously monitors the suction tip position and provides this information to the computer, which then adjusts the conveyance section to maintain precise positioning. This real-time feedback enables fast, accurate automated operation across multiple cells.

Inventive Principle:
Principle #23Feedback

3Manufacturing precision

If the suction tip position is controlled manually, then the system is easier to operate, but the precision in guiding the tip to specific cells is insufficient

Engineering Contradiction:
Improvetip positioning precisionVSAvoidoperational simplicity
Core Design Contradiction:
Manufacturing precisionVSEase of operation

Solution Approach 1:

The patent replaces manual mechanical positioning with computer-controlled automated positioning. The computer receives detection information about the suction tip position and automatically controls the conveyance section to achieve precise positioning, eliminating the need for manual operation while dramatically improving precision.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The optical detection system serves as an intermediary that provides precise positional information to the computer control system. This intermediary enables the computer to accurately determine and adjust the suction tip position, achieving high precision without requiring manual skill or effort.

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables precise and efficient suction of intracellular substances by automatically guiding the suction tip to the target cell, improving processing efficiency and flexibility, especially in handling multiple cells with high precision.

Implementation Method 1

a detection section configured to acquire information on a front end part of the tip

Methodology Applied
Scientific EffectOptical detection: Light

Implementation Method 2

a conveyance section configured to make the suction section three-dimensionally movable

Methodology Applied
Scientific EffectMechanical movement:

Implementation Method 3

a suction section including a tubular tip configured to suction the substance from the inside of the cell

Methodology Applied
Scientific EffectSuction: Suction

Data Source

PatentUS10458999B2Cell suction system, and method for performing suction work of intracellular substance using the same
Publication Date: 2019.10.29 YOKOGAWA ELECTRIC CORP
  • US10458999B2 patent drawing
  • US10458999B2 patent drawing
  • US10458999B2 patent drawing

AI summary

Provided is a cell suction system that supports suction work of a substance within a cell. The cell suction system includes: a suction section including a tubular tip configured to suction the substance from the inside of the cell received in a container; a detection section configured to acquire information on a front end part of the tip; and a conveyance section configured to make the suction section three-dimensionally movable, the conveyance section being configured to move the suction section to guide the front end part of the tip attached to the suction section into one specific cell based on the information obtained in the detection section.