Cell Tracking with Division-State Exclusion for Accurate Movement Analysis
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Solution Overview
Problem
Existing cell tracking technologies face challenges in accurately distinguishing between cell movement and division, leading to noise in analysis of cell movement states due to instantaneous changes in the center of gravity during cell division.
Innovation Solution
A cell tracking method that includes extracting tracking regions based on luminance information, determining cell division states, and excluding change information during division periods to analyze movement states accurately.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If cell tracking is performed continuously including during cell division, then tracking coverage is maintained, but noise is introduced in movement state analysis due to instantaneous center of gravity changes
Solution Approach 1:
The patent segments the tracking process into distinct phases: normal tracking mode and cell division detection mode. By dividing the tracking workflow into these separate functional segments, the system can apply different processing rules appropriate to each phase, thereby eliminating noise from division events while preserving tracking continuity through structured state transitions.
Solution Approach 2:
The patent extracts and isolates the cell division event from the continuous tracking data stream. By detecting division states separately and removing these specific data points before movement analysis, the system extracts the harmful noise component while retaining the useful movement information, thus improving analysis accuracy without losing overall tracking context.
2Measurement precision
If cell division events are excluded from tracking data, then movement analysis accuracy improves, but complete tracking information is lost
Solution Approach 1:
The patent applies local quality by treating different portions of the tracking data differently. Normal tracking data points are processed with standard movement analysis algorithms, while identified cell division data points are handled separately through exclusion or special marking. This localized differential processing ensures high precision in movement measurement while preserving the complete dataset for comprehensive analysis.
Solution Approach 2:
The patent changes the processing parameter state based on detected conditions. When a cell division event is detected, the system transitions from normal movement analysis parameters to division-exclusion parameters, effectively dynamically adjusting the analysis mode. This parameter change approach maintains measurement precision by applying appropriate processing rules while retaining all original tracking data for potential reanalysis.
3Measurement precision
If tracking region extraction is performed for each cell image, then tracking accuracy is maintained, but processing complexity increases
Solution Approach 1:
The patent performs preliminary extraction of tracking regions and identification of cell division states before conducting movement analysis. By preparing and pre-processing the tracking data, detecting division events in advance, and marking them for exclusion, the system simplifies the subsequent movement analysis process while maintaining high tracking accuracy through thorough preliminary processing.
Data Source
AI summary
A cell tracking method for performing cell tracking on the basis of a plurality of cell images captured in time series, including an extraction process of extracting a tracking region corresponding to the cell for each cell images; a tracking process of calculating a change information in a position of the extracted tracking region and tracking the cell on the basis of the change information; a determination process of determining whether or not the cell as a tracking target is in a cell division state on the basis of the cell image; and an analysis process of analyzing a movement state of the cell on the basis of the change information from which the change information in a period of the cell division state is excluded when the cell is determined to be in the cell division state in the determination process.