Cell Treatment Device with Rotating Electrode Unit
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Solution Overview
Problem
Current PEF equipment fails to maintain homogeneous process conditions, leading to uneven cell proliferation and treatment effects due to non-uniform flow and electric field profiles within the reaction vessel.
Innovation Solution
A device with a movable unit that rotates to position cell material between parallel electrodes, ensuring a uniaxial electric field application, which allows for homogeneous stimulation of cell growth and treatment, using electric pulses with controlled voltage and duration to achieve desired effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If cell material is continuously pumped through an arrangement of two electrodes in a reaction vessel, then the cell material can be treated with electric pulses, but non-uniform flow and electric field profiles are formed resulting in heterogeneous treatment conditions
Solution Approach 1:
The patent applies the dynamics principle by rotating the treatment vessel or electrode arrangement during electric pulse application. This rotational movement dynamically changes the position of cell material relative to the electric field, ensuring that all regions of the cell material experience uniform electric field exposure over time, thereby resolving the contradiction between continuous processing and treatment homogeneity.
Solution Approach 2:
The patent introduces a temporal dimension to the treatment process by applying electric pulses in sequential cycles while rotating the vessel. This transforms a static spatial problem into a dynamic temporal-spatial process, where different spatial positions are exposed to the electric field at different times, achieving overall uniformity through multi-dimensional coordination.
2Ease of operation
If a flow profile is formed between the wall and the center of the reaction vessel, then continuous processing is enabled, but deviations with respect to process conditions occur over the vessel diameter
Solution Approach 1:
By implementing rotational movement of the treatment vessel or electrodes, the patent converts the static flow profile problem into a dynamic system where different radial positions are sequentially exposed to the electric field. This ensures that despite continuous flow and associated velocity gradients, all cell material ultimately receives consistent treatment dosage.
Solution Approach 2:
The patent employs periodic electric pulse application combined with continuous rotation, creating a cyclic treatment regime where each portion of cell material experiences multiple pulses at different orientations. This periodic action compensates for flow-induced variations and ensures reliable, consistent treatment conditions throughout the continuous processing operation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach ensures consistent and controllable treatment conditions, enhancing cell proliferation and extraction of bioactive compounds by maintaining homogeneous electric field and flow profiles, thereby improving the efficiency of cell treatment processes.
Implementation Method 1
a unit for generating and emitting electric pulses, one treatment space capable of being penetrated by the emitted electric pulses and an electric field resulting therefrom
Implementation Method 2
said treatment space is provided between two electrodes or plates of a capacitor parallel to each other
Implementation Method 3
a unit which can be moved into and out of said treatment space such that cell material provided within a compartment of said unit, or provided in a container on or in said unit, can be moved into and out of said treatment space
Data Source
AI summary
The present invention relates to a device (1) for treating cells for stimulating cell growth, comprising a unit (2) for generating and emitting electric pulses and an electric field resulting therefrom, and a treatment space (3) that can be penetrated by the emitted electric pulses, wherein the device (1) further comprises a unit (4, 9) which can be moved into and out of said treatment space (3) such that cell material provided within a compartment (4a) of said unit (4), or provided in a container (5) on or in said unit (4, 9), can be moved into and out of said treatment space (3), and wherein said treatment space (3) is provided between two electrodes (2a, 2b) or plates of a capacitor parallel to each other.