Cellular Matrix Fluorescence Filtering to Reduce Scattering Noise
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Solution Overview
Problem
Conventional methods struggle to maintain sufficient optical power and filter out undesirable wavelengths in cellular matrices due to scattering and size constraints, which affect detectors and optogenetic systems.
Innovation Solution
A system comprising a light source, wavelength filters, fluorophores, scatterers, and a retroreflective frame is used to reduce scattering and enhance optical power density by filtering specific wavelengths and redirecting light within the cellular matrix.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Illumination intensity
If light is delivered to cellular matrices, then optogenetic functions are enabled, but scattering reduces optical power density and detectors struggle to detect light
Solution Approach 1:
The patent converts the harmful scattering effect into a beneficial mechanism by introducing scatterers that redirect light back through the cellular matrix. These scatterers, positioned at specific locations, transform the previously detrimental scattering into a useful light redistribution mechanism that maintains optical power density and improves detector signal strength.
Solution Approach 2:
The patent introduces intermediate components including wavelength filters and scatterers that mediate between the light source and the cellular matrix. These intermediaries selectively filter wavelengths and redirect light paths to maintain sufficient optical power density while reducing harmful scattering effects.
2Measurement precision
If filters are used to eliminate unwanted wavelengths, then noise is reduced, but device complexity increases
Solution Approach 1:
The patent segments the filtering function into multiple wavelength-specific filters positioned at different locations within the optical path. Each filter targets specific unwanted wavelengths, allowing the system to achieve comprehensive spectral filtering while maintaining manageable complexity through modular filter placement.
Solution Approach 2:
The patent applies different filtering characteristics at different locations within the optical path. Wavelength filters are strategically positioned to address specific scattering and detection issues at particular stages, allowing localized optimization of filter performance without requiring uniform filtering throughout the entire system.
3Volume of moving object
If the cellular matrix size is reduced for implantability, then device miniaturization is achieved, but maintaining sufficient optical power becomes difficult
Solution Approach 1:
The patent converts the harmful scattering effect into a beneficial mechanism by introducing scatterers that redirect light back through the cellular matrix. These scatterers, positioned at specific locations, transform the previously detrimental scattering into a useful light redistribution mechanism that maintains optical power density and improves detector signal strength.
Solution Approach 2:
The patent employs preliminary actions by pre-positioning wavelength filters and scatterers within the optical path before light reaches the cellular matrix. These components are arranged in advance to preemptively filter unwanted wavelengths and redirect light paths, ensuring sufficient optical power density is maintained even in reduced-size matrices.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively maintains a threshold optical power density and reduces noise by filtering out unwanted wavelengths and scattering events, ensuring consistent light delivery to detectors.
Implementation Method 1
a plurality of fluorophores configured to receive at least a portion of the source light and first light and generate a second light at a second wavelength
Implementation Method 2
the first filter is a polarization filter configured to provide the first light at a first polarization
Implementation Method 3
the other of the two filter is an absorptive filter to eliminate excitation light due to scattering events
Implementation Method 4
a plurality of scatterers arranged at the cellular matrix configured to return a portion of the light to increase an optical power density of the cellular matrix
Implementation Method 5
a frame arranged an outer edge of the cellular matrix to direct light in a direction opposite that of the source light
Data Source
AI summary
A system for reducing scattering and improving power density in cellular matrices, may include a light source configured to provide source light at a first wavelength to a cellular matrix, a first filter configured to receive the source light from the light source and provide a first light, a plurality of fluorophores configured to receive at least a portion of the source light and first light and generate a second light at a second wavelength, at least one second filter configured to receive at least a portion of the first light and second light and filter the first light and a detector configured to receive the second light from the at least one second filter to perform optogenetics on the cellular matrices.