Cellular Medicine Transfer Adapter with Dual Flow Channels
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Solution Overview
Problem
Conventional closed transfer systems for cellular medicines result in residue issues due to cell adhesion on vial walls, leading to incomplete transfer and potential inefficacy in administering the scheduled number of cells.
Innovation Solution
An adapter for cellular medicine containers with two flow channels that allow both liquid and cells to flow through, enabling repeated washing of the container interior during transfer, reducing residue and ensuring complete transfer of cells.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a conventional adapter with one liquid flow channel and one air-only flow channel is used, then contaminants are prevented from mixing with the medicine, but cells adhere to the inner wall of the vial and remain inside the vial causing residue
Solution Approach 1:
The adapter is divided into multiple flow channels (first liquid flow channel, second liquid flow channel, and air flow channel) with distinct functions. The first liquid flow channel allows liquid and cells to pass, the second liquid flow channel allows only liquid to pass, and the air flow channel allows only air to pass. This segmentation enables differentiated control of fluid and cell movement to prevent residue while maintaining contaminant prevention.
Solution Approach 2:
Different flow channels are designed with different local properties: the first liquid flow channel has properties that allow both liquid and cells to pass through, while the second liquid flow channel has properties that allow only liquid to pass. This local quality differentiation enables the system to achieve both complete cell transfer and contaminant prevention.
2Productivity
If air is used to push medicine out of the vial, then the medicine can be transferred, but cells are not uniformly diffused and adhere to the vial wall
Solution Approach 1:
The system uses liquid flow (hydraulics) instead of air flow (pneumatics) to push cells out of the vial. The first liquid flow channel allows liquid and cells to pass, enabling complete cell transfer without adhesion to the vial wall, while the air flow channel separately handles air flow for pressure equalization.
3Reliability
If the flow channel allows only air to pass through, then liquid cannot flow through, but this prevents complete transfer of cellular medicine
Solution Approach 1:
The adapter is divided into multiple flow channels with distinct functions: the first liquid flow channel for complete cellular medicine transfer, the second liquid flow channel for liquid-only flow, and the air flow channel for air-only flow and sterile barrier function. This segmentation resolves the contradiction by assigning different functions to different channels.
Solution Approach 2:
The adapter as a whole performs multiple functions through its different flow channels: complete cellular medicine transfer, contaminant prevention, and air pressure equalization. Each flow channel is optimized for its specific function while contributing to the overall multi-functionality of the adapter system.
Data Source
AI summary
A cellular medicine transfer system includes: an adapter for a cellular medicine container including a first flow channel and a second flow channel through each of which a liquid and cells can flow; a cellular medicine container to which the adapter is attached, and in which a cellular medicine to be transferred is stored; an administration medium storage container that communicates with the first flow channel, and in which an administration medium is stored; a collection container for collecting a cellular medicine, that communicates with the second flow channel of the adapter; and a powering device that imparts motive power for transferring the administration medium from the administration medium storage container through the first flow channel to the cellular medicine container, and for transferring the cellular medicine and the administration medium from the cellular medicine container through the second flow channel to the collection container.