Cellular Membrane Nanoparticles with Isotonic Cores for Targeted Delivery
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Solution Overview
Problem
Existing technologies lack effective nanoparticles that utilize cellular membranes for targeted drug delivery and immune response elicitation, particularly those that maintain isotonicity and enhanced steroid levels for improved stability and efficacy.
Innovation Solution
Development of nanoparticles comprising an interior compartment and an outer surface made from cellular membranes, where the interior is isotonic to physiological liquids and the outer surface has an enhanced steroid level, such as cholesterol, to enhance stability and targeting capabilities.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If cellular membranes are used for nanoparticle outer surface, then targeted delivery and immune response are improved, but stability and isotonicity are compromised
Solution Approach 1:
The patent modifies the physical and chemical parameters of the nanoparticle interior compartment by adjusting osmolarity, pH, and ionic composition to match physiological conditions. This parameter optimization stabilizes the cellular membrane while preserving its targeted delivery and immune response capabilities.
Solution Approach 2:
The nanoparticle employs a composite structure where a cellular membrane (natural material) is combined with a carefully formulated interior compartment containing buffers, osmolytes, and stabilizing agents (synthetic materials). This composite approach maintains membrane integrity while enabling controlled therapeutic delivery.
2Stability of the object's composition
If steroid levels are enhanced in cellular membrane, then stability and targeting capabilities are improved, but manufacturing complexity increases
Solution Approach 1:
The patent incorporates steroids (such as cholesterol) into the cellular membrane at enhanced levels during the membrane preparation stage, before nanoparticle assembly. This preliminary enrichment ensures stable membrane formation and improved targeting capabilities without requiring complex post-manufacturing modifications.
Solution Approach 2:
The cellular membrane naturally contains steroids that self-organize and stabilize the membrane structure. The patent leverages this self-service property by selecting cell sources with naturally high steroid content or by adding exogenous steroids that spontaneously integrate into the membrane, reducing the need for complex manufacturing controls.
Data Source
AI summary
The present disclosure relates to nanoparticles containing cellular membrane and uses thereof. The nanoparticle comprises an interior compartment (or an inner core) and an outer surface (or shell) comprising a cellular membrane derived from a cell, said interior compartment (or an inner core) not providing a solid support to said cellular membrane in said outer surface (or shell). The present disclosure also relates to processes of making the nanoparticles. The present disclosure further relates to compositions comprising the nanoparticles and methods of using the nanoparticles.