Cellulose Micropowder for Orally Disintegrating Tablets
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing cellulose powders used in orally disintegrating tablets often result in unsatisfactory ingestion feel due to roughness and dryness, and struggle with achieving both proper hardness and rapid disintegration, as they have low compression moldability and high water absorbency.
Innovation Solution
A cellulose powder with an average polymerization degree of 150 to 450, an average particle diameter of 10 to 100 μm, and a primary particle ratio of 50% or more, which is produced through spray-drying or pulverization, is used to improve compression moldability and disintegration properties, reducing saliva absorption and enhancing ingestion feel.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If conventional cellulose powder is used in orally disintegrating tablets, then rapid disintegration is achieved, but ingestion feel deteriorates due to roughness and dryness
Solution Approach 1:
The patent applies parameter changes by precisely controlling the average polymerization degree (150-450) and average particle diameter (10-100 μm) of cellulose powder. These parameter optimizations resolve the contradiction by achieving both rapid disintegration and smooth ingestion feel without roughness or dryness, as verified in Examples 1-9 where tablets showed quick disintegration and pleasant mouthfeel.
2Speed
If cellulose powder with high water absorbency is used, then disintegration properties improve, but tablet hardness deteriorates
Solution Approach 1:
The patent resolves this contradiction through parameter changes in cellulose powder characteristics, specifically controlling average polymerization degree (150-450) and average particle diameter (10-100 μm). These optimized parameters enable the tablet to achieve both rapid disintegration and sufficient hardness to prevent breakage during handling, as demonstrated in Examples 1-9 where tablets maintained integrity while disintegrating quickly in the mouth.
3Speed
If cellulose powder with low compression moldability is used, then disintegration properties improve, but manufacturing quality deteriorates
Solution Approach 1:
The patent applies parameter changes by optimizing cellulose powder properties (average polymerization degree: 150-450, average particle diameter: 10-100 μm) to achieve balanced compression moldability and disintegration properties. This resolves the contradiction by enabling good manufacturing quality while maintaining rapid disintegration, as shown in Examples 1-9 where tablets were successfully manufactured with consistent quality and quick disintegration performance.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The cellulose powder achieves satisfactory tablet hardness and rapid disintegration without feeling rough or dry, ensuring a well-balanced ingestion experience.
Implementation Method 1
an orally disintegrating tablet that is rapidly disintegrated with saliva or a small amount of water
Data Source
AI summary
The present invention relates to a cellulose powder usable for a satisfactory orally disintegrating tablet having excellent compression moldability and well-balanced tablet moldability and disintegration properties, which can obtain excellent ingestion feel without feeling roughness and dryness in the oral cavity, and more particularly to a cellulose powder with an average polymerization degree of 150 to 450, an average particle diameter of not less than 10 µm but less than 100 µm, and a primary particle ratio of 50% or more.