Cellulosic Interference Domain for Glucose Sensor Accuracy
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Solution Overview
Problem
Conventional electrochemical sensors for glucose measurement are prone to inaccuracies due to interference from species like acetaminophen, ascorbic acid, and uric acid, which cause increased signal strength and hinder precise glucose monitoring in diabetic patients.
Innovation Solution
An electrochemical sensor with a membrane system incorporating a cellulosic derivative interference domain, treated with ionizing radiation, is designed to resist the passage of interfering species, ensuring accurate glucose measurement by minimizing the impact of acetaminophen, ascorbic acid, and uric acid.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a conventional electrochemical sensor is used to measure glucose, then the sensor can detect electroactive species, but interfering species cause increased signal strength and measurement inaccuracy
Solution Approach 1:
The membrane system is divided into multiple functional domains: an interference domain containing cellulosic derivative to block interfering species, and an analyte domain to allow glucose and oxygen permeation. This segmentation enables selective transport where the interference domain specifically targets and blocks electroactive interferers while the analyte domain maintains glucose sensing functionality.
Solution Approach 2:
The cellulosic derivative in the interference domain acts as an intermediary barrier between the electrochemical cell and interfering species in biological fluid. This intermediary material selectively interacts with electroactive interferers through adsorption or binding, preventing them from reaching the electrode while allowing glucose to be measured accurately.
2Measurement precision
If the sensor membrane is made more selective to block interfering species, then measurement accuracy improves, but membrane complexity increases
Solution Approach 1:
The membrane system employs composite material construction by combining cellulosic derivative (for interference blocking) with other polymer materials (such as Nafion or polyurethane) to create a multi-functional membrane. This composite approach integrates interference rejection and analyte transport properties within a unified membrane structure, managing complexity through material composition rather than mechanical complexity.
3Reliability
If ionizing radiation is applied to treat the cellulosic derivative, then interference blocking capability improves, but manufacturing process complexity increases
Solution Approach 1:
Ionizing radiation treatment modifies the physical and chemical parameters of the cellulosic derivative, such as creating cross-linked structures or altering surface properties to enhance interference blocking. This parameter change approach transforms the material properties post-manufacturing through controlled radiation exposure, achieving improved reliability without fundamentally changing the manufacturing process architecture.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The sensor effectively blocks interfering species, providing improved accuracy in glucose monitoring, reducing false signals and enabling more timely and informed insulin therapy decisions for diabetic patients.
Implementation Method 1
a membrane system disposed on the electroactive surface, wherein the membrane system comprises an interference domain comprising at least one cellulosic derivative, wherein the membrane system is configured to resist interfering species
Implementation Method 2
wherein the interference domain is treated by exposure to ionizing radiation
Implementation Method 3
an analyte (or a species derived from it) that is electro-active generates a detectable signal at an electrode
Implementation Method 4
An enzyme is provided that reacts with the analyte to be measured
Implementation Method 5
an analyte (or a species derived from it) that is electro-active generates a detectable signal at an electrode
Data Source
AI summary
The present invention relates generally to devices for measuring an analyte in a host. More particularly, the present invention relates to devices for measurement of glucose in a host that incorporate a cellulosic-based interference domain.