Hydraulic Cement Implant Paste Shelf Life
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Solution Overview
Problem
Existing mineral reactive systems used in medical and technical applications face challenges such as limited shelf life, sensitivity to powder/liquid ratio, and complex mixing processes, which hinder their widespread adoption and effective use, especially in medical settings where user training and experience are limited.
Innovation Solution
Development of implant materials in the form of pastes, suspensions, or dispersions containing powdery and reactive solids like calcium and magnesium compounds, mixed with an aqueous liquid to form a solid body, using a carrier liquid that is not miscible with water, thereby extending shelf life and simplifying the mixing process.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If mineral reactive systems are used in the form of powder and liquid mixtures, then they can achieve cement-like curing reaction, but the shelf life is limited and the mixing process is complex
Solution Approach 1:
The patent combines the powder component and carrier liquid into a single paste formulation containing calcium phosphate powder, glycerol, and water in specific ratios. This merging eliminates the need for separate powder and liquid containers, extends shelf life by preventing premature reaction, and simplifies the mixing process to merely adding water at the time of use.
Solution Approach 2:
The patent performs preliminary mixing of the powder with glycerol and water to create a stable paste before storage. This preliminary action prepares the reactive components in a stable state that can be stored for extended periods without reacting, and only requires final water addition during application, thereby extending shelf life and simplifying the actual mixing process at use.
2Adaptability or versatility
If mineral reactive systems are used in medical applications, then they can serve as bone cements and adhesives, but user training and experience are required for proper preparation
Solution Approach 1:
The patent creates a self-service system where the paste is pre-formulated with optimal component ratios (calcium phosphate powder, glycerol, water) that automatically maintain stability during storage and provide consistent curing properties when water is added. This eliminates the need for users to measure or mix components, making the material easy to use regardless of user training or experience level.
3Reliability
If powder and liquid are mixed in complex ratios, then curing reaction can be controlled, but the quality of result depends on user ability and care
Solution Approach 1:
The patent merges the powder component with glycerol and water in a pre-determined ratio within the paste formulation. This ensures that the reactive components are always in the correct proportions, eliminating variability caused by user mixing errors and ensuring consistent curing reaction and result quality across all applications.
Solution Approach 2:
The patent changes the physical state and composition parameters by incorporating glycerol as a carrier liquid and controlling the water content (0.1-10% by weight) to optimize both shelf stability and curing properties. This parameter optimization ensures reliable curing reaction while maintaining ease of use and consistent results.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides implant materials with extended shelf life and improved handling, allowing for multiple applications, including bone cements and adhesives, by ensuring stability and consistency through the use of non-aqueous carrier liquids, reducing the complexity of mixing, and enhancing mechanical properties.
Implementation Method 1
using a carrier liquid that is not miscible with water, thereby extending shelf life and simplifying the mixing process
Implementation Method 2
containing powdery and reactive solids like calcium and magnesium compounds, mixed with an aqueous liquid to form a solid body
Implementation Method 3
react in a cement-like curing reaction to a solid material
Data Source
AI summary
The invention relates to implant materials that are based on hydraulic cements in the form of one or more pastes, suspensions or dispersions that contain mineral and/or organic and/or organomineral solids and that react, when combined or when reacted with an aqueous liquid, to a solid in a cement-type initiation reaction. The invention also relates to the use of these materials as technical, medical-technical and/or pharmaceutical products, especially as bone cements, bone replacement materials, bone glues, dental filling materials and implantable active ingredient carriers. The implant materials according to the invention in the form of one or more pastes, suspensions or dispersions that contain mineral and/or organic and/or organomineral solids are formulated in an excipient liquid in such a manner that the pastes, suspensions or dispersions are stable in storage at normal conditions over a prolonged period of time and that they react, when combined with an aqueous liquid or when added to an aqueous liquid, in a cement-type initiation reaction and set to a solid. The excipient liquid of the mineral paste, suspension or dispersion is substantially water-free, and water immiscible or insoluble or hardly soluble in water in the chemical sense.