Centrifugal Detection Channel With Buffer Control Valve
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Solution Overview
Problem
Current automatic analyzers for sample detection are bulky, expensive, and complex, making them unsuitable for on-site sampling and rapid testing, and existing microfluidic valves are costly and difficult to produce, limiting the ability to detect multiple reagents simultaneously.
Innovation Solution
A centrifugal detection channel and device utilizing a buffer control valve that prevents liquid flow through surface tension and air pressure, with a transient chamber acting as both a valve and buffer to manage reagent flow, allowing for single or multiple reagent detection without additional processing or devices.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Extent of automation
If commercial automatic analyzers are used to achieve automated detection, then detection automation is improved, but device size and cost increase
Solution Approach 1:
The patent divides the detection system into modular components: a microfluidic chip containing reaction chambers and channels, a centrifugal module for fluid manipulation, and a detection module. This segmentation allows automated detection functionality to be achieved in a compact, integrated format rather than requiring a large centralized system
Solution Approach 2:
The system uses centrifugal force generated by the rotating chip to automatically perform multiple operations including sample transport, reagent mixing, and phase separation without requiring external mechanical actuators or complex control mechanisms. The centrifugal field enables the system to be self-sufficient for fluid manipulation
2Ease of operation
If microfluidic valves are used to control liquid flow, then liquid positioning is improved, but manufacturing complexity and cost increase
Solution Approach 1:
The microfluidic channels incorporate hydrophobic sections that automatically control liquid flow based on surface tension principles. The liquid stops at the hydrophobic barrier without requiring external actuation, and continues flowing only when centrifugal force overcomes the surface tension. This self-regulating mechanism eliminates the need for complex valve structures
Solution Approach 2:
The patent replaces traditional mechanical valve systems with a passive hydrophobic barrier mechanism. Instead of using moving parts, motors, or complex mechanical structures to control flow, the system uses surface tension properties of hydrophobic materials combined with centrifugal force to achieve precise liquid positioning and flow control
3Device complexity
If only one reaction chamber is used, then device simplicity is maintained, but multiple reagent detection capability is lost
Solution Approach 1:
The microfluidic chip is divided into multiple independent reaction chambers, each capable of holding different reagents. The channels connecting these chambers are designed with hydrophobic valves that can be independently activated. This segmentation allows the system to perform multiple detection reactions simultaneously while maintaining a relatively simple overall structure
Solution Approach 2:
The patent designs a universal microfluidic platform where multiple reaction chambers and channels share common structural elements and control mechanisms. The same centrifugal driving force and hydrophobic valve principles apply to all chambers, allowing the system to detect multiple reagents using a single integrated device rather than requiring separate specialized devices for each detection
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables efficient, cost-effective, and portable detection of single or multiple reagents, reducing production complexity and enabling on-site and rapid testing by controlling reagent flow effectively.
Implementation Method 1
By utilizing a unique buffer control valve, it can prevent the liquid from advancing without additional processing and devices with the action of surface tension and air pressure.
Implementation Method 2
By utilizing a unique buffer control valve, it can prevent the liquid from advancing without additional processing and devices with the action of surface tension and air pressure.
Implementation Method 3
the transient chamber in the buffer control valve can hold the dripping liquid as buffering during the process to prevent the liquid from entering the subsequent chamber too early
Implementation Method 4
Centrifugal detection channel, detection device and detection method
Data Source
AI summary
The present invention discloses a kind of centrifugal detection channel, including: a first chamber, at least one inlet channel, at least one buffer valve, at least one outlet channel, and a second chamber. Specifically, at least one inlet channel is connected to the first chamber. At least one buffer valve is connected to the inlet channel, including: a valve body and a transient chamber. At least one outlet channel is connected to the buffer valve. At least one second chamber is connected to the outlet channel. In addition, the detection devices and the detection methods comprising the centrifugal detection channel have also been proposed.