Centrifugal Liquid Release via Deformable Capsule and Sharp Edge
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Solution Overview
Problem
Current liquid storage methods in microfluidic chips face challenges with incomplete and uncontrolled release of reagents, leading to inaccurate detection due to residual liquid and incompatibility with enclosed biological detection processes like nucleic acid lysis and amplification.
Innovation Solution
A liquid storage and controlled-release device featuring a deformable liquid storage capsule with a sealing layer and a directional release chamber, where the sealing layer is broken by a sharp edge to allow complete and quantitative release of liquid driven by centrifugal force, ensuring no residue and maintaining an enclosed environment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If liquid is stored in a film bag with a predetermined breaking point and pressure is applied to release the liquid, then liquid can be released from the storage unit, but the liquid cannot be completely released and residual liquid remains in the film bag
Solution Approach 1:
The invention extracts the liquid release function from the film bag structure itself and separates it into a dedicated release channel. The breaking point is positioned at the outlet of the release channel rather than within the storage chamber, allowing liquid to be completely expelled through the channel while the film bag can be fully compressed without leaving residue.
Solution Approach 2:
The release channel acts as an intermediary between the liquid storage space and the external environment. It provides a controlled pathway for liquid expulsion, ensuring complete release while preventing residue formation in the storage unit. The channel structure mediates the transition from stored liquid to released liquid efficiently.
2Quantity of substance
If pressure is applied to compress the film bag to release liquid, then liquid can be forced out of the storage unit, but air pressure in the overall system increases which is unsuitable for enclosed biological detection chips
Solution Approach 1:
The invention segments the system into a sealed storage chamber and a separate release channel system. The breaking point is located at the outlet of the release channel, allowing liquid to be expelled through this dedicated pathway. This segmentation enables liquid release without requiring system-wide pressure increases, as the breaking mechanism is localized and does not compromise the sealed environment of the main chip system.
3Adaptability or versatility
If liquid storage method is used in microfluidic chips, then the range of applicable reagents is expanded compared to solid storage, but the liquid cannot be quantitatively released without residue affecting detection accuracy
Solution Approach 1:
The invention extracts the liquid release function from the general storage system and implements it through a dedicated release channel with a specifically positioned breaking point. This extraction allows the storage chamber to maintain its versatility for different liquid reagents while the release mechanism ensures quantitative expulsion without residue, thereby preserving detection accuracy.
Solution Approach 2:
The release channel serves as an intermediary structure that enables quantitative liquid release while maintaining the versatility of the storage system. It provides a controlled pathway that ensures complete liquid expulsion regardless of the specific reagent type, thus mediating between the diverse storage requirements and the precise release needs for accurate detection.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables precise and complete release of liquid reagents, enhancing the accuracy of subsequent detection processes and maintaining the integrity of the enclosed environment required for biological detection chips.
Implementation Method 1
The substrate is driven to rotate by a centrifugal force
Data Source
AI summary
A liquid storage and controlled-release device and a biological detection chip. The liquid storage and controlled-release device comprises a liquid storage capsule with a liquid storage body which is deformable under a pressure, and a sealing layer for sealing the liquid storage body. A support platform is provided right below the liquid storage capsule and tightly connected with the liquid storage capsule, wherein, a directional release chamber is provided at the middle of the support platform, and the directional release chamber is provided with a guiding chamber for collecting the liquid and a sharp edge for inducing break. Compared with the conventional technology, the opening for liquid release is at the end far away from the rotation center, so that the liquid can be released completely by the centrifugal force, ensuring the quantitative release of stored liquid and reducing the influence on the accuracy of the subsequent detection.