Centrifugal Micro-Fluidic Device for Simultaneous Assays
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Solution Overview
Problem
Conventional disk type micro-fluidic devices are limited in their ability to simultaneously conduct multiple immunosorbent assays and require complex processes, making them time-consuming and incompatible with biochemical analysis, necessitating separate equipment for each type of assay.
Innovation Solution
A centrifugal micro-fluidic device with a disk type platform featuring multiple chambers, channels, and valves that utilize centrifugal force for fluid transport, along with binders that selectively bind to target materials for optical signal detection, enabling simultaneous immunosorbent and biochemical analyses.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If a conventional disk type micro-fluidic device is used for immunosorbent assay, then the assay can be performed on a single platform, but the device structure becomes complex and can only detect a few analytes simultaneously
Solution Approach 1:
The device divides the disk platform into multiple independent assay units, each capable of performing separate immunosorbent assays. Each unit contains its own sample chamber, reagent chambers, and micro-fluidic channels, allowing simultaneous detection of multiple analytes while keeping each unit's structure relatively simple and modular.
Solution Approach 2:
The patent transitions from a planar chip structure to a three-dimensional disk platform with multiple layers. This vertical stacking enables multiple assay units to be arranged in different radial zones and layers, increasing the number of simultaneous assays without proportionally increasing the footprint area, thus managing structural complexity while enhancing versatility.
2Productivity
If a conventional disk type micro-fluidic device with complex micro-fluidic structure is used, then immunosorbent assay can be performed, but the testing time is extended due to complicated processes
Solution Approach 1:
Reagents are pre-loaded into designated chambers before the assay begins. The device is prepared with all necessary components in place, allowing the actual testing process to start immediately without time-consuming setup steps, thus reducing overall test duration while maintaining efficient processing.
Solution Approach 2:
The micro-fluidic channels are designed to enable continuous flow and mixing of samples and reagents throughout the assay process. Multiple reactions occur simultaneously in parallel channels without interruption, eliminating idle time between steps and maximizing productivity across all assay units.
3Adaptability or versatility
If separate equipment is used for biochemical analysis and immunosorbent assay, then each assay type can be optimized, but multiple equipment setups are required increasing complexity
Solution Approach 1:
The disk platform is designed as a universal system that can accommodate both immunosorbent assays and biochemical analyses. By providing configurable chambers, channels, and detection interfaces that work for multiple assay types, the device eliminates the need for separate equipment setups while maintaining optimization for each specific assay through proper configuration of the shared platform.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device allows for rapid and simultaneous performance of multiple immunosorbent and biochemical assays on a single platform, reducing the need for multiple equipment setups and streamlining the testing process while maintaining accurate detection of target materials.
Implementation Method 1
the fluid is transported via centrifugal force generated by rotation of the rotational body
Implementation Method 2
a first binder provided in the micro-fluidic structure wherein the binder selectively binds to a target material and contains solid particles as a detection label required for expressing optical signals
Data Source
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AI summary
Disclosed are a centrifugal micro-fluidic device and an immunosorbent assay method using the same. In particular, a centrifugal micro-fluidic device having a plurality of micro-fluidic structures placed in a disc type platform to simultaneously conduct several immunosorbent assays, as well as an immunosorbent assay method using the same are provided.