Centrifugal Pump Pulsatile Perfusion Using Physiological Waveforms
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Solution Overview
Problem
Current perfusion technologies, particularly those using centrifugal pumps, fail to provide pulsatile flow necessary for adequate organ perfusion, leading to neurovascular and metabolic morbidities, and require manual control of multiple discrete apparatuses, increasing the risk of errors.
Innovation Solution
A system and method that uses a graphical user interface to control a centrifugal pump based on measured physiological pressure or flow waveforms, converting these waveforms to voltage signals to operate a mechanical pump for pulsatile or continuous blood perfusion, integrating multiple components with a single controller for efficient and error-reduced operation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If manual control of multiple discrete apparatuses is used, then operation flexibility is maintained, but error risk increases and ease of operation deteriorates
Solution Approach 1:
The patent combines multiple discrete apparatuses (waveform generator, amplifier, pump controller) into a single integrated system controlled through one graphical user interface. This merging reduces the number of separate control interfaces and manual operations required, thereby reducing error risk while maintaining operational flexibility through unified control.
Solution Approach 2:
The single controller system performs multiple functions including waveform generation, signal amplification, pump control, and monitoring. This multi-functional integration allows one system to replace multiple discrete apparatuses, improving reliability by reducing interconnections between separate devices while maintaining comprehensive control capabilities.
2Productivity
If centrifugal pumps are used for perfusion, then continuous flow is achieved, but pulsatile flow capability is lost
Solution Approach 1:
The system dynamically controls the centrifugal pump's rotational speed using generated waveforms, transforming it from a device that only provides continuous flow to one that can deliver pulsatile flow. The pump's operational parameters are continuously adjusted based on the applied waveform signals, enabling adaptable flow patterns while maintaining continuous operation.
Solution Approach 2:
The system changes the operational parameters of the centrifugal pump by applying voltage waveforms that modulate rotational speed. This allows the pump to transition between continuous and pulsatile flow modes, providing waveform control capability while maintaining the benefits of centrifugal pump operation.
3Manufacturing precision
If waveform conversion and amplification are implemented, then pump control precision is improved, but device complexity increases
Solution Approach 1:
The waveform generation, amplification, and pump control functions are merged into a single integrated system rather than separate discrete components. This integration reduces the overall system complexity despite the sophisticated control functions, as the components work together through unified software control and shared hardware resources.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively mimics native physiological waveforms, reducing hemolysis and errors by dynamically controlling a centrifugal pump through a single interface, ensuring accurate and efficient pulsatile perfusion for extended cardiopulmonary bypass and isolated organ preservation.
Implementation Method 1
converting the offset-removed waveform to a voltage waveform based on the one or more parameters; and operating, via the voltage waveform, a pump
Implementation Method 2
operating, via the voltage waveform, a centrifugal pump to provide perfuse blood
Data Source
AI summary
Aspects of the present disclosure generally relate to systems and methods for perfusion, and more specifically, for pulsatile blood perfusion based on a measured pressure waveform. One example method generally includes receiving, via a graphical user interface presented to a user, datapoints indicating a waveform; receiving one or more parameters associated with blood perfusion; generating an offset removed waveform based on the datapoints, the offset removed waveform having a physiological offset removed; converting the offset-removed waveform to a voltage waveform based on the one or more parameters; and operating, via the voltage waveform, a pump to provide blood in a perfusion system. The aspects described herein are applicable for any suitable perfusion environment, such as extracorporeal perfusion or isolated organ perfusion.