Integrated Centrifugal Sample Preparation in Shipping Container
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Solution Overview
Problem
Current methods for collecting and preparing bodily fluid samples are cumbersome, error-prone, and require trained personnel, making it difficult for patients without access to laboratories to obtain and transport samples for diagnostic testing.
Innovation Solution
A centrifugal separation system integrated within a shipping container that allows for self-application and stabilization of biological samples, including a rotor with a counter-balancing weight, motor, and pre-programmed PCB for efficient separation and stabilization, along with wireless communication for data transmission.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If simple collection methods are used, then ease of operation is improved, but sample preparation reliability deteriorates
Solution Approach 1:
The collection device automatically performs sample preparation functions through integrated mechanisms. The device self-activates upon closure, automatically centrifuges the sample, and stabilizes it without requiring user intervention or training, thereby maintaining ease of operation while ensuring reliable sample preparation.
Solution Approach 2:
The patent combines multiple functions (collection, centrifugation, stabilization, and shipping) into a single integrated device. This merging allows the simple-to-use collection process to automatically include reliable sample preparation steps that would otherwise require separate manual operations and trained personnel.
2Reliability
If trained personnel are used for sample collection, then sample preparation reliability is improved, but device complexity increases
Solution Approach 1:
The device is designed to automatically perform all sample preparation functions without requiring trained personnel. The self-activating mechanism and integrated centrifugal separation system handle complex tasks automatically, eliminating the need for specialized training while maintaining reliable sample preparation.
Solution Approach 2:
The patent replaces manual mechanical operations (performed by trained personnel) with an automated centrifugal separation system. The rotor and motor assembly automatically perform separation tasks that would otherwise require skilled manual manipulation, reducing device complexity from a human-operated system to an automated mechanical system.
3Stability of the object's composition
If multiple preparation steps are used, then sample stability is improved, but loss of time increases
Solution Approach 1:
The device performs stabilization actions immediately upon sample collection and closure. The centrifugal separation and stabilization processes are initiated automatically without delay, ensuring sample stability is established early in the process while minimizing the time the sample remains vulnerable to degradation.
Solution Approach 2:
The patent ensures continuous sample preparation from collection through stabilization to shipping. The automated system maintains uninterrupted processing, eliminating idle time between steps and ensuring the sample remains under controlled conditions throughout the entire workflow, thereby achieving both stability and time efficiency.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables rapid, reliable, and cost-effective collection, preparation, and transportation of biological samples, ensuring sample integrity and accessibility for patients in non-clinical environments without the need for specialized training or equipment.
Implementation Method 1
a centrifugal separation system that is contained within a shipping container
Implementation Method 2
the rotor contains an opening for a biological sample and an integrated counter-balancing weight
Data Source
AI summary
The disclosed apparatus, systems and methods relate to sample preparation and shipping technologies in a single shippable container. The shipping container contains a single use centrifuge. The centrifuge can be temperature controlled and meets all standards and regulations for the shipping and transport of biological specimens.