Centrifugal Sample Sorting Structure for Complete Sample Discharge
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Solution Overview
Problem
Conventional centrifugal sorting methods for samples result in low efficiency, manual intervention, high labor costs, and incomplete discharge of samples due to complex structures and expensive consumables.
Innovation Solution
A sample sorting structure with a centrifugal chamber assembly, rotation and translation driving assemblies, and a spindle system that enables simultaneous centrifugation and squeezing separation, allowing automated sample stratification and complete discharge into containers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of substance
If centrifugal force alone is used for sample discharge, then the centrifugal chamber structure can be simple, but samples cannot be completely discharged resulting in high residual amount
Solution Approach 1:
The patent combines the centrifugal chamber with a pressing platform that can be moved along the spindle axis. The pressing platform is driven by a translation driving assembly to press samples against the centrifugal chamber wall, merging the centrifugal separation function with the mechanical pressing discharge function into a single integrated structure.
Solution Approach 2:
The pressing platform is designed to be movable along the spindle axis rather than fixed. The translation driving assembly dynamically adjusts the position of the pressing platform to optimize the pressing action on samples, enabling complete discharge while maintaining a relatively simple centrifugal chamber structure.
2Productivity
If centrifugation and sorting are carried out separately, then each process can be optimized independently, but sorting efficiency is low and target cells may be mixed with other cells
Solution Approach 1:
The patent performs centrifugation and sorting simultaneously within the same centrifugal chamber. The rotation driving assembly provides centrifugal force for both separation and sorting processes at the same time, eliminating the need for separate centrifugation and sorting steps, thereby improving sorting efficiency while maintaining separation effectiveness through the combined action of centrifugal force and the pressing platform.
3Extent of automation
If manual intervention is used for sample sorting, then equipment structure can be simple, but labor costs are high and automation cannot be achieved
Solution Approach 1:
The pressing platform is automatically controlled by the translation driving assembly to move along the spindle axis and press samples against the centrifugal chamber wall. The rotation driving assembly automatically provides centrifugal force for separation and sorting. This self-service mechanism eliminates manual intervention while maintaining a relatively simple device structure through automated control of the pressing and rotation processes.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Improves sample separation efficiency, enhances utilization, and reduces costs by automating the process and ensuring complete sample collection.
Implementation Method 1
a centrifugal chamber assembly, which has a centrifugal inner cavity; a rotation driving assembly for driving the centrifugal chamber assembly to rotate
Implementation Method 2
a pressing platform fixed at the end of the spindle extending into the centrifugal inner cavity, wherein the pressing platform is configured to load a sample bag to be sorted and be moved by the spindle towards or away from a side of the centrifugal inner cavity for pressing the sample bag to be sorted
Data Source
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AI summary
A sample sorting structure (100), comprising: a centrifugal chamber assembly (101), the centrifugal chamber assembly (101) having a centrifugal inner cavity (101a); a rotation driving assembly (102) for driving the centrifugal chamber assembly (101) to rotate; a spindle (103), the spindle (103) being synchronously rotatably connected to the centrifugal chamber assembly (101), and one end of the spindle (103) extending to the centrifugal inner cavity (101a) and being movable relative to the centrifugal inner cavity (101a); an extrusion platform (104) fixed at the end of the spindle (103) extending to the centrifugal inner cavity (101a), the extrusion platform (104) being used for loading a sample bag to be sorted, and is driven by the spindle (103) to move close to or away from the end of the centrifugal inner cavity (101a) used for extruding the sample bag to be sorted; and a horizontal pushing driving assembly (105) for driving the spindle (103) to move in the centrifugal inner cavity (101a), the horizontal pushing driving assembly (105) being rotatably connected to the spindle (103). The sample sorting structure uses an automatic mode of extruding and sorting while centrifuging, improving sample sorting efficiency, making it easier to completely discharge samples, improving sample utilization, and reducing costs. Further disclosed are a sample sorting method based on the sample sorting structure, and a related device.