Centrifugal Separation Kit with Integrated Injector for Blood Processing
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Solution Overview
Problem
Current methods for extracting Platelet Rich Plasma (PRP) from whole blood are inefficient, often requiring excessive time, leading to inconsistent collections and increased consumable usage, which complicates clinical applications and increases costs, especially in private hospitals where automated equipment is not readily available.
Innovation Solution
A centrifugal separation kit comprising a centrifugal separation tube with a collecting unit and a cell isolation gel, along with an injector, is designed to efficiently separate blood into Red Blood Cell and Platelet Rich Plasma layers, reducing consumable usage and improving collection accuracy by optimizing the volume ratios and structural features of the kit components.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If manual centrifugal separation is performed using separate injectors and tubes, then blood components can be separated, but the process consumes excessive time and requires multiple consumables
Solution Approach 1:
The patent combines the collecting unit and separation tube into a single integrated centrifugal separation kit. The collecting unit is pre-installed within the separation tube, eliminating the need for separate collectors and reducing the number of transfer steps. This integration directly reduces waiting time while maintaining collection accuracy through optimized component positioning.
Solution Approach 2:
The collecting unit is pre-positioned within the separation tube before centrifugal separation begins. The lower cap is pre-filled with cell isolation gel, and the collecting unit is adjusted to the appropriate height based on blood volume predictions. This preliminary arrangement eliminates setup time during the separation process and ensures accurate collection from the outset.
2Reliability
If multiple separate injectors and tubes are used for collection and separation, then complete separation can be achieved, but consumable usage increases
Solution Approach 1:
The patent integrates the collecting unit and separation tube into one system, eliminating the need for separate collection vessels. This single-integration approach maintains complete separation functionality while reducing consumable usage by eliminating redundant tubes and injectors.
Solution Approach 2:
The centrifugal separation tube serves multiple functions: it acts as both the separation chamber and the collection vessel. The collecting unit within the tube can collect separated components directly, eliminating the need for separate collection containers and reducing overall consumable requirements.
3Ease of operation
If the collecting unit is positioned at the top of the separation tube, then collection is simple, but it cannot effectively separate blood components
Solution Approach 1:
The collecting unit is positioned vertically within the separation tube at a height optimized for separation effectiveness, not at the top. This vertical positioning allows the unit to collect components after they have properly separated by density during centrifugal rotation, maintaining both separation effectiveness and collection simplicity through proper spatial arrangement.
Solution Approach 2:
The collecting unit is pre-adjusted to the optimal height within the separation tube before centrifugal separation begins. This preliminary positioning ensures that when separation occurs, the collecting unit is already in the correct position to effectively collect the separated blood components, eliminating the need for post-separation adjustment.
4Measurement precision
If cell isolation gel is added to separate layers, then separation accuracy improves, but the process becomes more complex
Solution Approach 1:
The cell isolation gel is integrated into the lower cap of the separation tube, combining the gel containment and separation functions into a single component. This integration maintains high separation accuracy while reducing process complexity by eliminating separate gel addition steps and reducing the number of discrete components.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables stable and efficient extraction of Platelet Rich Plasma, reducing waiting times in surgical procedures and lowering the cost of consumables by minimizing the need for separate injectors and tubes, thus enhancing working efficiency and reliability.
Implementation Method 1
a centrifugal separation tube including a collecting unit installed therein and having a collecting tube, the centrifugal separation tube having a coupling unit installed to a lower portion of the centrifugal separation tube and having a tube insert portion communicating with the inside of the centrifugal separation tube, and a lower cap installed to the coupling unit of the centrifugal separation tube and filled with a predetermined amount of cell isolation gel
Implementation Method 2
the blood is divided into three layers of a Red Blood Cell (RBC) layer, a Platelet Rich Plasma (PRP) layer containing a lot of platelets, a Platelet Poor Plasma (PPP) layer from the bottom of a centrifugal separation tube 2 due to the specific weights
Data Source
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AI summary
A centrifugal separation kit is used for centrifugally separating whole blood and body fluid, and a method for centrifugal separation using the kit. The centrifugal separation kit is capable of easily extracting a target substance by installing an injector to a centrifugal separation tube and collecting the centrifugally separated target substance with the injector.