Centrifuge Sample Holder With Integrated Camera For Real-Time Imaging
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Solution Overview
Problem
Current centrifuge systems are limited in their ability to image multiple test elements simultaneously during centrifugation, restricting the number of samples that can be processed efficiently and requiring expensive high-quality cameras, and lack automated verification of test element suitability for centrifuging.
Innovation Solution
Incorporating a camera into the centrifuge sample holder to image the mixing of biological samples with a test medium while centrifuging, allowing for real-time monitoring and verification of sample integrity and reaction progress, enabling the centrifugation of multiple samples without the need for extensive manual intervention.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If multiple test elements are carried by the centrifuge, then the productivity increases, but the imaging time for each test element decreases and the field of vision is more obstructed
Solution Approach 1:
The patent divides the imaging function into multiple independent cameras, each assigned to image a specific test element. This segmentation allows simultaneous imaging of multiple test elements during centrifugation, eliminating the time loss associated with sequential imaging while maintaining high productivity
Solution Approach 2:
The patent transitions from a single-point imaging approach to a distributed multi-point imaging approach by positioning multiple cameras at different locations around the centrifuge rotor. This dimensional expansion enables parallel observation of multiple test elements without obstructing each other's field of vision
2Measurement precision
If a high-quality camera is used to capture images of test elements during centrifugation, then the measurement precision improves, but the device complexity and cost increase
Solution Approach 1:
The patent uses multiple simple cameras positioned at strategic locations to capture images of test elements during centrifugation. By distributing the imaging function across multiple simpler devices rather than relying on a single complex high-quality camera, the system achieves the same measurement precision while reducing overall device complexity and cost
Solution Approach 2:
The patent makes each camera serve a specific imaging function for a particular test element, allowing the use of simpler, more cost-effective cameras that are optimized for their specific imaging task rather than requiring a single expensive camera to handle all imaging requirements
3Reliability
If manual verification of test element suitability is performed, then the reliability of results improves, but the productivity decreases due to extensive manual intervention
Solution Approach 1:
The patent implements automated feedback loops where cameras continuously monitor test elements during centrifugation, and the captured images are automatically analyzed to verify sample integrity and reaction progress. This automated feedback system maintains high reliability by detecting anomalies while eliminating the need for manual intervention, thus preserving productivity
Solution Approach 2:
The patent enables the centrifuge system to perform self-verification of test element suitability through automated imaging and analysis. The system independently monitors sample integrity, detects improper test elements, and can automatically adjust or alert operators, eliminating the need for external manual verification while maintaining reliability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables efficient processing of multiple samples by allowing real-time imaging and verification, reducing centrifugation time and improving the reliability of results, while maintaining cost-effectiveness by automating manual steps and optimizing sample handling.
Implementation Method 1
A centrifuge is an apparatus that puts an object in rotation around a fixed axis, applying a strong outward force perpendicular to the axis of spin. A centrifuge works using the sedimentation principle, where the centripetal acceleration causes denser substances and particles to move outward in the radial direction.
Implementation Method 2
A centrifuge works using the sedimentation principle, where the centripetal acceleration causes denser substances and particles to move outward in the radial direction. At the same time, objects that are less dense are displaced and move to the center.
Data Source
AI summary
A method of testing a biological sample, the method comprising: providing a centrifuge sample holder having a camera; arranging a transparent container comprising a fluid test medium in a recess of said centrifuge sample holder, wherein the camera is arranged to image a portion of the container comprising said fluid test medium; arranging said biological sample above and not in contact with said fluid test medium in said container; and with the camera, imaging a mixing of said biological sample with said fluid test medium while centrifuging the sample holder.