CeONP Blood Storage Inserts for Longer Unrefrigerated Preservation

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Solution Overview

Problem

Current blood storage methods are time-limited, leading to unusable blood and blood products, especially in situations requiring lengthy and/or unrefrigerated storage, necessitating improved compositions and techniques for extended storage life.

Innovation Solution

The use of cerium oxide nanoparticles (CeONPs) in blood storage containers, either as a coating or in a liquid/solid composition, to increase the storage life of blood and blood products by maintaining their integrity and functionality.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of stationary object

If current blood storage methods are used, then storage is possible, but storage life is time-limited leading to unusable blood

Engineering Contradiction:

Improvestorage lifeVSAvoidblood usability

Core Design Contradiction:

Duration of action of stationary objectVSReliability

Solution Approach 1:

The patent applies parameter changes by introducing cerium oxide nanoparticles to alter the chemical environment within the blood storage container. The CeONPs catalyze the removal of residual glucose and modify metabolic parameters, thereby extending storage life while maintaining blood usability. This resolves the contradiction by changing the biochemical parameters of the storage system rather than relying on conventional refrigeration alone.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs composite materials by combining cerium oxide nanoparticles with the blood storage container system. The CeONPs form a composite preservation system that works synergistically with existing storage conditions to extend shelf life. This composite approach enables longer storage durations while preserving blood quality, addressing both the duration and reliability concerns.

Inventive Principle:

Principle #40Composite materials

2Adaptability or versatility

If lengthy and/or unrefrigerated storage is needed, then flexibility is improved, but blood degradation increases

Engineering Contradiction:

Improvestorage flexibilityVSAvoidblood degradation

Core Design Contradiction:

Adaptability or versatilityVSObject-affected harmful factors

Solution Approach 1:

The cerium oxide nanoparticles act as an intermediary substance that mediates between the blood and the storage environment. The CeONPs catalyze protective biochemical reactions and scavenge harmful radicals, thereby protecting blood from degradation during flexible storage conditions. This intermediary mechanism enables unrefrigerated or extended storage without compromising blood integrity.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent converts potentially harmful residual glucose and metabolic byproducts into beneficial effects by using CeONPs to catalyze their removal. The nanoparticles transform the harmful metabolic activity that normally degrades stored blood into a controlled process that actually preserves blood quality during extended storage, turning the harm of prolonged storage into a benefit of extended shelf life.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Data Source

PatentUS12484576B2Blood preservation compositions, devices, and uses thereof

Publication Date: 2025.12.02 MILLIFLUIDICA

AI summary

Described herein are blood storage containers that can contain a CeONP composition and/or coating on an object surface. In some aspects, the blood storage container can include an insert. In some aspects the inserts can contain a CeONP compositions and/or coating on an object surface. In aspects, the CeONP composition and/or coating on an object surface can be effective to increase the useful storage lifespan of blood, blood product, and/or component thereof stored in the blood storage container. Also described herein are methods of making and using the CeONP compositions, coatings, and devices containing the CeONP compositions and/or coatings described herein.