Ceramide Capsule Shell Composition for Aqueous Stability

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Solution Overview

Problem

It is challenging to incorporate ceramides into cosmetic compositions, particularly those with high water content, as existing methods struggle to maintain their stability and effectiveness.

Innovation Solution

The development of ceramide-containing capsules with a specific shell composition, including polycaprolactone, block copolymers, and surfactants, which encapsulate ceramide NP, hydroxypalmitoyl sphinganine, and 2-oleamido-1,3-octadecanediol, along with hydroxyacetophenone as a preservative, allowing for stable incorporation into various cosmetic compositions, including water-based ones.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If ceramides are incorporated into cosmetic compositions with large amounts of water, then the cosmetic composition can be more hydrating and easier to apply, but the ceramide stability and effectiveness deteriorate

Engineering Contradiction:

Improvewater contentVSAvoidceramide stability

Core Design Contradiction:

Quantity of substanceVSStability of the object's composition

Solution Approach 1:

The ceramide composition is segmented into multiple functional components: ceramide NP (2-10%), hydroxypalmitoyl sphinganine (2-10%), and 2-oleamido-1,3-octadecanediol (10-40%), each serving specific roles in maintaining stability while allowing high water content. This segmentation allows the composition to achieve both hydration and ceramide stability

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The patent uses a composite material system combining ceramides with hydroxypalmitoyl sphinganine and 2-oleamido-1,3-octadecanediol in specific ratios. This composite approach creates synergistic effects that enhance ceramide stability in aqueous environments while maintaining the desired hydrating properties of high-water cosmetic compositions

Inventive Principle:

Principle #40Composite materials

2Ease of manufacture

If conventional methods are used to incorporate ceramides, then the formulation process is simpler, but the ceramide effectiveness and skin barrier functionality deteriorate

Engineering Contradiction:

Improveformulation simplicityVSAvoidceramide effectiveness

Core Design Contradiction:

Ease of manufactureVSReliability

Solution Approach 1:

The patent specifies precise parameter ranges for ceramide composition (2-10% ceramide NP, 2-10% hydroxypalmitoyl sphinganine, 10-40% 2-oleamido-1,3-octadecanediol) that optimize both formulation ease and ceramide effectiveness. These parameter changes ensure proper incorporation while maintaining skin barrier functionality

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

Hydroxypalmitoyl sphinganine and 2-oleamido-1,3-octadecanediol act as intermediary substances that facilitate ceramide incorporation into cosmetic compositions. These intermediaries improve ceramide effectiveness and skin barrier functionality while maintaining formulation simplicity

Inventive Principle:

Principle #24Intermediary (Mediator)

3Stability of the object's composition

If more preservatives like phenoxyethanol are used, then the cosmetic composition stability improves, but the product safety and skin compatibility deteriorate

Engineering Contradiction:

Improvecosmetic composition stabilityVSAvoidskin irritation

Core Design Contradiction:

Stability of the object's compositionVSObject-affected harmful factors

Solution Approach 1:

The patent reduces reliance on conventional preservatives like phenoxyethanol by using a stable ceramide composition system that inherently resists degradation. The specific ceramide ratio (2-10% ceramide NP, 2-10% hydroxypalmitoyl sphinganine, 10-40% 2-oleamido-1,3-octadecanediol) provides natural stability, allowing minimal preservative usage and improving skin compatibility

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The ceramide compositions improve skin barrier functionality, promote regeneration, and enhance moisture retention, providing improved skin appearance and anti-inflammatory effects while reducing the need for preservatives like phenoxyethanol.

Implementation Method 1

ceramide containing capsules... comprising: (i) a shell, and (ii) a core encapsulated by the shell

Methodology Applied

Scientific EffectEncapsulation:

Implementation Method 2

The shell comprises: (a) polycaprolactone, (b) a block copolymer, and (c) a surfactant

Methodology Applied

Scientific EffectSurfactant: Surfactant

Data Source

PatentUS11007134B1Ceramide containing capsules, ceramide compositions, and cosmetic compositions thereof

Publication Date: 2021.05.18 LOREAL SA

AI summary

The ceramide composition includes capsules dispersed in the ceramide composition, the capsules comprising a shell and a core. The shell includes a polycaprolactone, a block copolymer, and a surfactant. The core includes ceramide NP, hydroxypalmitoyl sphinganine, 2-oleamido-1,3-octadecanediol, and a hydrophobic solvent. The core has a weight ratio of the ceramide NP of (i) and the hydroxypalmitoyl sphinganine of (ii) to the 2-oleamido-1,3-octadecanediol of (iii) is from 1:2.5 to 1:5. Additionally, the ceramide composition includes hydroxyacetophenone and hydrophilic solvent.