Ceramide Composition for Dermal-Epidermal Junction Reinforcement
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Solution Overview
Problem
Skin aging results in structural and physiologic alterations, including compromised dermal-epidermal junction (DEJ) integrity, leading to mechanical instability, reduced adhesion, and impaired cell-cell communication, which are not effectively addressed by existing cosmetic products.
Innovation Solution
A composition comprising ceramides of formula I, specifically Cer NS, LacCer, Cer NP, and Cer NG, is applied topically or orally to strengthen the DEJ, promote cell adhesion, and enhance intercellular communication, thereby improving skin firmness, hydration, and reducing signs of aging.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If conventional cosmetic products are used, then general skin care is provided, but the DEJ structure and cell adhesion are not effectively strengthened
Solution Approach 1:
The patent changes the chemical parameters of the active ingredients by using specific ceramide molecules with defined fatty acid chains (C16-C34) and sugar moieties (lactosyl, glucosyl, or no sugar). This molecular-level parameter change enables the composition to specifically target and strengthen the DEJ structure, resolving the contradiction between providing general skin care and achieving effective DEJ reinforcement.
Solution Approach 2:
The patent employs composite ceramide molecules that combine sphingoid base, fatty acid, and optionally sugar moieties in specific configurations. These composite molecular structures provide both structural reinforcement of the DEJ and functional benefits for cell adhesion, simultaneously addressing the need for strength and reliability in anti-aging effects.
2Stability of the object's composition
If skin aging is allowed to progress, then natural skin function is maintained, but mechanical stability and adhesion are compromised
Solution Approach 1:
The patent applies ceramide compositions before significant DEJ degradation occurs, preventing the weakening of mechanical stability and adhesion. By introducing the active ingredients in advance, the composition maintains structural integrity and prevents the progression of age-related degradation, resolving the contradiction between maintaining natural function and preserving mechanical strength.
Solution Approach 2:
The ceramide molecules act as intermediary substances that mediate between the epidermis and dermis, reinforcing the DEJ structure and maintaining mechanical stability. These intermediary ceramide compounds facilitate strong adhesion while preserving the natural functional architecture of the skin, preventing the compromise that occurs with aging.
3Productivity
If extracellular matrix degrading enzymes are elevated, then tissue repair is enhanced, but basement membrane proteins are degraded
Solution Approach 1:
The patent converts the harmful effect of elevated proteolytic activity into a beneficial outcome by using ceramide compositions that selectively protect basement membrane proteins while allowing controlled tissue repair. The ceramides act as protective agents that prevent excessive degradation of structural proteins, transforming the potential harm of enzyme elevation into a controlled repair process that preserves essential structural integrity.
Data Source
AI summary
Cosmetic use of a composition for reducing and/or ameliorating signs of skin aging in an individual, wherein the composition comprises a compound of formula I, wherein the carbon-carbon bond noted Formula II is a double or a single bond, R1 is an alkyl chain having 10-20 carbon atoms, R2 is hydrogen or a substituted or unsubstituted acyl having 16-34 carbon atoms, R3 is hydrogen when the carbon-carbon bond noted Formula II is a double or a single bond, or R3 is —OH when the carbon-carbon bond noted Formula II is a single bond, R4 is hydrogen when the carbon-carbon bond noted Formula II is a double or a single bond, or R4 is hydrogen or —OH when the carbon-carbon bond noted Formula II is a double bond, X is hydrogen or a glycosyl moiety, wherein the glycosyl moiety is a lactosyl moiety or a glucosyl moiety.