Ceramide Liquid Crystal Composition for Skin Barrier Repair
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Solution Overview
Problem
Current liquid crystal compositions containing ceramide suffer from instability and limited ceramide inclusion, which hampers their practical application in providing effective moisturizing and protective functions for the skin.
Innovation Solution
A liquid crystal composition is developed, comprising a water phase and an oil phase with ceramide, cholesterol or its derivatives, and fatty acids, along with an emulsifier, to enhance stability and skin lipid inclusion, allowing for improved skin moisturization and barrier function.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If ceramide is included in a large amount in liquid crystal composition, then moisturizing and protective functions are improved, but stability of the liquid crystal deteriorates
Solution Approach 1:
The patent uses a composite material system consisting of ceramide, cholesterol, and fatty acid in specific molar ratios (1:1:1 to 1:2:2) to create a stable liquid crystal composition. This composite approach allows high ceramide content (0.1-20 wt%) while maintaining liquid crystal stability through the synergistic interaction of multiple lipid components that mimic natural skin barrier structure.
Solution Approach 2:
The patent optimizes the molar ratios of ceramide, cholesterol, and fatty acid, as well as the weight percentage of ceramide (0.1-20 wt%), to achieve both high ceramide inclusion and liquid crystal stability. By adjusting these parameters within specific ranges, the composition maintains stability while maximizing moisturizing and protective functions.
2Quantity of substance
If ceramide is included in a large amount in liquid crystal composition, then skin barrier repair and regeneration are improved, but practical usability deteriorates
Solution Approach 1:
The patent formulates a composite lipid system with ceramide, cholesterol, and fatty acid that mimics the natural skin barrier structure. This composite material provides effective skin barrier repair and regeneration at high ceramide levels while maintaining the liquid crystal phase and stability required for practical cosmetic product usability.
Solution Approach 2:
The patent optimizes ceramide content within 0.1-20 wt% and maintains specific molar ratios to ensure both effective skin barrier repair and practical product performance. This parameter optimization allows the composition to be both highly effective and practically usable in cosmetic formulations.
Data Source
AI summary
Provided a liquid crystal composition including ceramide, a method of preparing the same, and a cosmetic composition including the same. According to a liquid crystal composition including various types of ceramide of an aspect and a method of preparing the same, the liquid crystal composition not only has high liquid crystal stability that liquid crystal is maintained even after 4 weeks at a high temperature, but also activities of increasing an amount of ceramide, increasing an expression level of aquaporin 3, increasing an amount of filaggrin, increasing an expression level of hyaluronic acid, increasing an expression level of loricrin, increasing an expression level of involucrin, and increasing a thickness of the skin, resulting in effects usefully available for amelioration of the skin conditions.