Ceramide Nanoparticle Stabilization via Microfluidic Self-Assembly
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Solution Overview
Problem
Ceramide, a crucial component for skin barrier function, is poorly soluble and difficult to stabilize in cosmetic formulations, leading to low skin absorption and instability in cosmetic products.
Innovation Solution
Ceramide is stabilized by preparing nanoparticles using a low-temperature microfluidic chip technology in combination with bioactive substances like β-sitosterol, resveratrol, and allantoin, which improves stability and skin absorption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If ceramide is used as a cosmetic material, then skin barrier improvement function is enhanced, but formulation stability and skin absorption rate decrease due to poor solubility
Solution Approach 1:
The patent changes the physical state and size parameters of ceramide by converting it into nanoparticles with specific size ranges (50-200 nm diameter). This parameter transformation improves solubility and stability without compromising the skin barrier improvement function, as the nanoparticulate form maintains ceramide's biological activity while enhancing its physical properties for cosmetic formulation
Solution Approach 2:
The patent creates a composite nanoparticle system containing ceramide combined with other lipids and active ingredients. This composite approach allows ceramide to be stabilized within a multi-component nanoparticle structure that improves overall formulation stability and skin absorption while maintaining the core skin barrier benefits
2Reliability
If ceramide is used as a cosmetic material, then skin barrier improvement function is enhanced, but skin absorption rate decreases due to structural specificity
Solution Approach 1:
The patent transforms ceramide into nanoparticle form with controlled size parameters (50-200 nm), which significantly improves skin absorption rate. The nanoparticulate size enables better penetration through the stratum corneum while preserving ceramide's skin barrier improvement function, effectively resolving the absorption limitation caused by its original structural specificity
3Stability of the object's composition
If low-temperature microfluidic chip technology is used to prepare nanoparticles, then stability and skin absorption rate are improved, but device complexity increases
Solution Approach 1:
The patent replaces conventional high-temperature and high-pressure nanoparticle preparation methods with low-temperature microfluidic chip technology. This substitution maintains formulation stability by avoiding thermal degradation while achieving consistent nanoparticle formation, though it introduces more complex microfluidic device requirements
4Reliability
If ceramide is contained in cosmetic material, then skin barrier function is improved, but usability and transparency decrease due to poor solubility
Solution Approach 1:
The patent converts ceramide into nanoparticle form with optimized size parameters, which dramatically improves solubility in cosmetic formulations. This enables better usability and transparency in the final cosmetic product while maintaining the skin barrier improvement function, as the nanoparticulate form allows for clearer, more stable formulations
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The stabilized ceramide nanoparticles exhibit enhanced skin moisturizing, anti-oxidation, anti-inflammatory, skin barrier enhancement, and skin irritation relief effects due to improved stability and skin absorption.
Implementation Method 1
passing the oil phase portion and the aqueous phase portion through a microfluidic chip to self-assemble the oil phase portion and the aqueous phase portion
Implementation Method 2
forming nanoparticles using a microfluidizer
Implementation Method 3
preparing a freeze-dried powder containing ceramide, resveratrol, and β-sitosterol
Data Source
AI summary
The present invention relates to a method for stabilizing ceramide and to a cosmetic composition containing stabilized ceramide and, more specifically, to a method for homogenizing and stabilizing ceramide by self-assembling the ceramide together with β-sitosterol, resveratrol, and allantoin which are other physiologically active substances using a microfluidic chip and a high pressure homogenizer, and to a technique for using ceramide and nanoparticles containing β-sitosterol, resveratrol, and allantoin, which are produced by means of the stabilizing method, as a cosmetic material for skin moisturizing, anti-oxidation, skin inflammation relief, skin barrier enhancement, and skin itching relief.