Ceramides and Palmitic Acid Amide Solubilization in Liquid Composition
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing topical formulations containing ceramides and palmitic acid amides face challenges with solubility and stability, leading to dispersion issues and quality concerns in cosmetic products aimed at preventing and counteracting skin inflammatory processes.
Innovation Solution
A stable liquid composition is achieved by dissolving ceramides and palmitic acid amides in Phytosteryl/Octyldodecyl Lauroyl Glutamate, which fully solubilizes these components, enhancing their stability and usability in topical formulations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If ceramides and palmitic acid amides are used in topical formulations, then anti-inflammatory efficacy is improved, but solubility and stability deteriorate
Solution Approach 1:
The patent uses Phytosteryl/Octyldodecyl Lauroyl Glutamate as an intermediary solubilizing agent that mediates between the poorly soluble active ingredients (ceramides and palmitic acid amides) and the aqueous formulation base. This mediator enables the active ingredients to be incorporated into stable liquid or semi-liquid topical formulations without compromising their anti-inflammatory efficacy.
Solution Approach 2:
The patent changes the physical-chemical parameters of the formulation system by introducing a specific solubilizing agent that alters the solubility characteristics of ceramides and palmitic acid amides. By modifying the formulation composition to include Phytosteryl/Octyldodecyl Lauroyl Glutamate, the system transitions from unstable dispersion to stable solution, maintaining therapeutic effectiveness.
2Stability of the object's composition
If heating process at high temperatures is used to dissolve waxes, then solubility is improved, but degradation of other raw materials occurs
Solution Approach 1:
The patent changes the temperature parameter of the processing conditions by using a solubilizing agent that enables dissolution at lower temperatures. Phytosteryl/Octyldodecyl Lauroyl Glutamate facilitates the incorporation of ceramides and palmitic acid amides without requiring high-temperature heating, thereby preventing thermal degradation of sensitive raw materials while achieving complete solubility.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The resulting liquid composition provides a stable and effective solution for topical use, improving the solubility and stability of ceramides and palmitic acid amides, thereby enhancing their anti-inflammatory properties in addressing skin inflammatory processes and inflamm-aging.
Implementation Method 1
both ceramides and palmitic acid amides can be dissolved in a single step by mixing with the Phytosteryl/Octyldodecyl Lauroyl Glutamate (INCI), which is able to fully solubilise the two components
Data Source
Figure 1
Figure 2~3
Figure 4~5
AI summary
Liquid composition consisting of: a) at least one ceramide b) at least one palmitic acid amide of formula (I) CH3 (CH2)14CONHR1 (I) and c) di-(phytosteryl-2-octyldodecyl)-N-lauroyl-L-glutamate wherein R1 is a straight or branched alkyl selected from the group consisting of a C1-C6 straight or branched alkyl optionally substituted with a hydroxyl group, a C4-C6 cycloalkyl, and wherein said components (a) and (b) are dissolved in said component (c).