Cerium Compound Composition for Uremic Toxin and Phosphorus Adsorption
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Solution Overview
Problem
Existing treatments for kidney disease, particularly those involving uremic toxins and hyperphosphatemia, suffer from inefficiencies and side effects, necessitating a more effective therapeutic agent that can suppress the elevation of serum creatinine, blood urea nitrogen, and serum phosphorus levels while minimizing gastrointestinal absorption and deposition.
Innovation Solution
A pharmaceutical composition containing a cerium compound, coated with a dispersant to control particle size and prevent complex formation, is used as an adsorbent for uremic toxins and phosphorus, with a production method that includes steps of mixing cerium salt, hydrogen peroxide, and a hydroxide ion source to achieve fine particle formation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If carbonaceous adsorbent preparation is used to remove uremic toxins, then uremic toxin levels are reduced, but gastrointestinal absorption and deposition of the adsorbent occurs
Solution Approach 1:
The patent changes the chemical composition parameters by using cerium compounds instead of traditional carbonaceous adsorbents. The cerium compound's specific chemical properties enable effective adsorption of uremic toxins while avoiding gastrointestinal absorption and deposition issues associated with conventional adsorbents.
Solution Approach 2:
The cerium compound acts as a transient adsorbent that performs its function in the gastrointestinal tract and is excreted in feces, similar to the disposable nature of traditional adsorbents. However, it provides superior performance with fewer side effects and no accumulation in the body.
2Reliability
If phosphorus adsorbent is used to suppress hyperphosphatemia, then serum phosphorus levels are reduced, but gastrointestinal absorption and deposition occurs
Solution Approach 1:
The patent employs cerium compounds with specific chemical parameters that enable effective phosphorus adsorption. The cerium compound's surface properties and chemical composition allow it to bind phosphorus in the gastrointestinal tract while being excreted without absorption or deposition, overcoming the limitations of conventional phosphorus adsorbents.
3Duration of action of moving object
If existing therapeutic agents are used to delay kidney disease progression, then renal function is compensated, but no cure exists and dialysis therapy is eventually required
Solution Approach 1:
The patent converts the harmful accumulation of uremic toxins and phosphorus into a beneficial treatment approach. By using cerium compounds to adsorb these toxins in the gastrointestinal tract, the therapy actively removes harmful substances rather than merely compensating for renal function loss, potentially extending the duration before dialysis is required.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The cerium compound demonstrates superior adsorptivity to uremic toxins and phosphorus, reducing serum creatinine, blood urea nitrogen, and serum phosphorus levels, while minimizing gastrointestinal absorption and side effects, making it an effective oral therapeutic agent.
Implementation Method 1
The cerium compound demonstrates superior adsorptivity to uremic toxins and phosphorus
Implementation Method 2
mixing cerium salt, hydrogen peroxide, and a hydroxide ion source to achieve fine particle formation
Implementation Method 3
coated with a dispersant to control particle size and prevent complex formation
Data Source
AI summary
Primarily aimed at providing a novel pharmaceutical composition. The present invention relates to a pharmaceutical composition that contains a cerium compound as an active ingredient.