CEST-MRI Cancer Characterization Using Synchronized HRV and RF Signals

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Solution Overview

Problem

Conventional systems lack the capability to employ measured hemodynamic parameters (Hdp) and heart rate variability (HRV) values to determine specific types of cancer or other health conditions in patients, and existing cancer diagnosis systems do not effectively utilize low-energy electromagnetic carrier output signals for diagnosis and treatment.

Innovation Solution

A system that includes an ECG monitoring system, an electrically powered generator, and a processing system to detect and measure RRI values, calculate HRV values, and expose patients to low-energy electromagnetic carrier output signals to diagnose and treat health conditions, utilizing amplitude modulation frequencies ranging from 0.01 Hz to 150 kHz to influence cellular functions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If conventional Hdp monitoring and ECG systems are used to measure heart rate metrics and RRI values, then basic cardiovascular parameters can be obtained, but the capability to determine specific types of cancer or health conditions is lacking

Engineering Contradiction:
Improvediagnosis precisionVSAvoiddiagnosis capability
Core Design Contradiction:
Measurement precisionVSAdaptability or versatility

Solution Approach 1:

The system integrates multiple functions into a single platform: Hdp monitoring, ECG recording, HRV analysis, and electromagnetic signal generation. This multi-functional system can diagnose various health conditions including different types of cancer, cardiovascular diseases, and neurological disorders using the same hardware and software infrastructure, thereby improving both measurement precision and diagnostic versatility

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The system analyzes multiple physiological parameters simultaneously (Hdp values, RRI intervals, HRV metrics) and changes in these parameters over time during electromagnetic exposure. By monitoring parameter changes rather than static values, the system can identify specific health conditions and cancer types with higher precision

Inventive Principle:
Principle #35Parameter changes

2Adaptability or versatility

If low-energy electromagnetic carrier output signals are applied to patients during exposure periods, then cellular functions can be influenced for diagnosis and treatment, but the system complexity increases

Engineering Contradiction:
Improvetreatment capabilityVSAvoidsystem complexity
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The electromagnetic signal generator is integrated with the existing Hdp monitoring and ECG recording systems. The same processing system that analyzes cardiovascular data also controls electromagnetic signal generation and interpretation, merging multiple functions into a unified system that reduces overall complexity while expanding treatment capabilities

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The system uses low-energy electromagnetic carrier signals as an intermediary to influence cellular functions indirectly. Rather than applying direct physical or chemical treatments, the electromagnetic signals modulate cellular activity, which is then detected through changes in Hdp and ECG parameters, providing a non-invasive diagnostic and therapeutic mechanism

Inventive Principle:
Principle #24Intermediary (Mediator)

3Measurement precision

If HRV values and Hdp values are integrated with intelligent learning library for analysis, then specific health conditions can be identified, but the processing time and computational complexity increase

Engineering Contradiction:
Improvecondition identification accuracyVSAvoidprocessing time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The intelligent learning library is pre-populated with reference data, diagnostic algorithms, and treatment protocols for various health conditions. During patient evaluation, the system compares real-time measurements against this pre-prepared knowledge base, enabling rapid identification of health conditions without requiring extensive computational analysis during the actual diagnostic process

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The system continuously monitors Hdp and ECG parameters during electromagnetic exposure and provides real-time feedback to the processing system. This feedback loop allows the intelligent learning library to adaptively refine diagnoses based on observed physiological responses, improving identification accuracy while maintaining efficient processing through iterative rather than exhaustive analysis

Inventive Principle:
Principle #23Feedback

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system effectively diagnoses and treats health conditions by identifying specific electromagnetic field amplitudes that influence cellular functions, providing accurate cancer diagnosis and treatment through HRV analysis and hemodynamic parameter monitoring.

Implementation Method 1

an electrically powered generator adapted to be actuated to generate the low-energy electromagnetic carrier output signals for exposing or applying the low-energy electromagnetic carrier output signals to the patient

Methodology Applied
Scientific EffectElectromagnetic radiation: Electromagnetic Induction

Implementation Method 2

Electrocardiography, which involves measuring heart rate metrics, can also be used to measure the bio-potential generated by electrical signals that control the expansion and contraction of heart chambers

Methodology Applied
Scientific EffectElectrical conduction in biological tissue: Conduction (electrical)

Implementation Method 3

a processing system that may be configured to synchronize the ECG monitoring system and the electrically powered generator

Methodology Applied
Scientific EffectSignal synchronization:

Data Source

PatentEP3876832B1Chemical exchange saturation transfer system for characterization, diagnosis, and treatment of a health condition
Publication Date: 2025.07.30 AUTEM MEDICAL LLC
  • EP3876832B1 patent drawingFigure 1
  • EP3876832B1 patent drawingFigure 2
  • EP3876832B1 patent drawingFigure 3

AI summary

A system and method for treating cancer by integrating a hemodynamic parameter (Hdp) monitoring system and a radiofrequency generator synchronized by a processing system is disclosed. The system is capable of identifying health condition-specific Hdp variation values changes in a patient upon the exposure of low energy amplitude modulated electromagnetic fields frequencies. A system and method for treating cancer by integrating a hemodynamic parameter (Hdp) monitoring system, a radiofrequency generator synchronized by a processing system, and a chemical exchange saturation transfer (CEST)-MRI system is further disclosed. The exposure of the modulated frequencies influences cellular functions, such as microtubule conductivity or cellular metabolism,1460 or malfunctions in a patient and can provide both a therapeutic and predictive and prognostic effect for the patient, providing for both treatment of a specific ailment or disease such as hepatocellular carcinoma as well as predictive results of how effective the treatment is likely to be. The construction of a library of frequencies can be used to more efficiently and effectively diagnose and treat a health condition in patients by auto-tuning a treatment regimen specifically to the patient.