Dual-Modality Liposomal Agent for Tumor Localization
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Solution Overview
Problem
Current imaging techniques for surgical oncology, particularly in lung cancer and head and neck cancer, face challenges such as the inability to accurately localize small, non-visible tumors and radiation exposure issues during minimally invasive surgeries, necessitating the development of novel imaging agents for improved pre-operative and intra-operative guidance.
Innovation Solution
A dual-modality x-ray computed tomography (CT) and near-infrared (NIR) fluorescence liposome-based agent (CF800) is developed, comprising an iodinated contrast agent and indocyanine green co-encapsulated inside a liposomal carrier, which provides enhanced contrast and fluorescence visualization for tumor localization and lymph node involvement.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If CT-guided micro-coil placement is performed for intraoperative localization of small pulmonary nodules, then tumor localization capability is improved, but radiation exposure to patient and surgical staff increases
Solution Approach 1:
The patent combines CT contrast agent and optical imaging agent into a single dual-modality liposomal agent, allowing both CT-guided preoperative localization and intraoperative optical visualization to be achieved with one agent, thereby reducing the need for repeated radiation exposure during surgery
Solution Approach 2:
The liposomal agent serves multiple functions: it provides CT contrast for preoperative planning, optical contrast for intraoperative visualization, and potential therapeutic delivery, eliminating the need for separate agents and reducing overall radiation exposure from multiple procedures
2Measurement precision
If intraoperative fluoroscopy is used for coil visualization during surgery, then real-time guidance is improved, but radiation exposure to surgical staff increases
Solution Approach 1:
The patent replaces the fluoroscopy-based mechanical imaging system with an optical imaging system that uses near-infrared fluorescence detection, eliminating radiation exposure to surgical staff while maintaining real-time visualization capability during surgery
3Adaptability or versatility
If multiple imaging agents are used for CT and optical imaging, then imaging versatility is improved, but device complexity and procedural time increase
Solution Approach 1:
The patent merges CT contrast agent and optical imaging agent into a single dual-modality liposomal formulation, simplifying the procedural workflow from administering multiple separate agents to a single combined agent while maintaining both imaging capabilities
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The CF800 agent significantly improves pre-, intra-, and post-operative imaging performance by offering prolonged contrast enhancement and accurate tumor margin identification, reducing radiation exposure and enhancing surgical precision through dual-modality imaging.
Implementation Method 1
an iodinated contrast agent... provides significant pre-, intra- and post-operative contrast enhancement of blood vessels, soft tissue and tumor
Implementation Method 2
indocyanine green co-encapsulated inside a liposomal carrier... provides significant pre-, intra- and post-operative contrast enhancement... accurate tumor margin identification
Data Source
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AI summary
The present application relates to compositions comprising an iodinated contrast agent and indocyanine green co-encapsulated inside a liposomal carrier, various uses thereof as well as methods for their preparation.