CGM Sensor Potential Modulation for Sensitivity Compensation

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Existing continuous glucose monitoring (CGM) sensors face challenges with sensor errors due to factors like temperature variations, hematocrit, and sensitivity changes, leading to inaccuracies and the need for frequent calibrations, especially in non-whole blood environments.

Innovation Solution

Implementing probing potential modulations (PPMs) on CGM sensors to alternately switch between steady-state and non-steady-state conditions, using PPM currents like i43 for accurate analyte concentration determination, reducing warm-up time, and minimizing interference from background signals.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If conventional continuous glucose monitoring sensors operate under steady-state conditions, then measurement stability is maintained, but measurement precision deteriorates due to sensor sensitivity changes and background interference

Engineering Contradiction:

Improveglucose concentration accuracyVSAvoidsensor sensitivity stability

Core Design Contradiction:

Measurement precisionVSReliability

Solution Approach 1:

The patent applies periodic potential modulation (probing potential modulations) to the sensor electrode, alternating between steady-state and non-steady-state conditions. This periodic switching enables the system to capture both stable baseline measurements and dynamic response characteristics, allowing for real-time compensation of sensor sensitivity changes and improvement of glucose concentration measurement accuracy without requiring frequent calibrations

Inventive Principle:

Principle #19Periodic action

2Measurement precision

If sensors are deployed in non-whole blood environments with constant temperatures, then temperature-related errors are reduced, but other sensor error sources emerge requiring frequent calibrations

Engineering Contradiction:

Improveglucose measurement accuracyVSAvoidcalibration frequency

Core Design Contradiction:

Measurement precisionVSDevice complexity

Solution Approach 1:

The patent implements a self-calibration mechanism where the sensor performs its own sensitivity adjustment by alternating between steady-state and non-steady-state measurements. The system uses the ratio of currents obtained during non-steady-state conditions to automatically compensate for sensitivity drift, eliminating the need for external calibration procedures and reducing device complexity related to calibration management

Inventive Principle:

Principle #25Self-service

3Measurement precision

If probing potential modulations are applied to switch between steady-state and non-steady-state conditions, then measurement accuracy improves, but energy consumption increases

Engineering Contradiction:

Improveanalyte concentration determination accuracyVSAvoidsensor power consumption

Core Design Contradiction:

Measurement precisionVSUse of energy by moving object

Solution Approach 1:

The patent applies probing potential modulations only during specific measurement intervals rather than continuously, switching between steady-state and non-steady-state conditions periodically. This partial application of potential modulation achieves the necessary accuracy improvement for analyte concentration determination while minimizing unnecessary energy consumption during stable measurement periods

Inventive Principle:

Principle #16Partial or excessive action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

PPMs enable more accurate and rapid glucose monitoring by compensating for sensor sensitivity changes and background interference, potentially eliminating the need for frequent calibrations and reducing initial decay, thus enhancing the reliability and efficiency of CGM systems.

Implementation Method 1

Methodology Applied

Scientific EffectProbing potential modulation:

Implementation Method 2

The sensor includes an enzyme layer and an outer membrane

Methodology Applied

Scientific EffectEnzyme catalysis: Enzyme

Implementation Method 3

The sensor includes an enzyme layer and an outer membrane

Methodology Applied

Scientific EffectDiffusion: Diffusion

Data Source

PatentEP4192348B1Non-steady-state determination of analyte concentration for continuous glucose monitoring by potential modulation

Publication Date: 2025.10.01 ASCENSIA DIABETES CARE HLDG AG

Figure 1A~1B
Figure 2A~2C
Figure 2D~2F

AI summary

A method of determining glucose values during continuous glucose monitoring (CGM) measurements includes providing a CGM device including a sensor, a memory, and a processor; applying a constant voltage potential to the sensor; measuring a primary current signal resulting from the constant voltage potential and storing the measured primary current signal in the memory; applying a probing potential modulation sequence to the sensor; measuring probing potential modulation current signals resulting from the probing potential modulation sequence and storing measured probing potential modulation current signals in the memory; determining an initial glucose concentration based on a conversion function and a measured probing potential modulation current signal; determining a connection function value based on the primary current signal and a plurality of the probing potential modulation current signals; and determining a final glucose concentration based on the initial glucose concentration and the connection function value. Other aspects are disclosed.