CH010365 Hybrid Corn Breeding for Uniform Trait Combinations

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Solution Overview

Problem

Existing corn breeding techniques struggle to develop hybrids that combine desirable traits such as increased yield, disease resistance, and uniformity while maintaining genetic stability and commercial viability.

Innovation Solution

The development of the hybrid corn variety CH010365, which incorporates genetic modifications and cytoplasmic traits like male sterility, along with specific breeding methods to ensure uniformity and desirable characteristics, and the use of engineered nucleases for precise genome editing to introduce traits like herbicide resistance and disease resistance.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If traditional breeding methods are used to develop hybrid corn varieties, then genetic diversity and trait combination are improved, but breeding time and complexity increase significantly

Engineering Contradiction:
Improvetrait combinationVSAvoidbreeding time
Core Design Contradiction:
Adaptability or versatilityVSLoss of time

Solution Approach 1:

The patent applies preliminary action by pre-developing and maintaining inbred parental lines with specific desirable traits before hybridization. These inbred lines are prepared in advance through multiple generations of self-pollination and selection, so that when hybridization occurs, the desired traits are already consolidated in the parental genomes, significantly reducing the time needed for trait combination compared to traditional breeding.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The breeding process is segmented into distinct phases: developing inbred parental lines with specific traits, maintaining those lines through controlled self-pollination, and then combining them through hybridization. This segmentation allows parallel development of multiple parental lines with different traits, which can then be combined in systematic crosses, reducing overall breeding time while maintaining genetic diversity.

Inventive Principle:
Principle #1Segmentation

2Stability of the object's composition

If self-pollination is used to develop homozygous inbred plants, then genetic uniformity is improved, but loss of genetic diversity occurs

Engineering Contradiction:
Improvegenetic uniformityVSAvoidgenetic diversity
Core Design Contradiction:
Stability of the object's compositionVSAdaptability or versatility

Solution Approach 1:

The breeding program segments the population into multiple distinct inbred lines, each homozygous and genetically uniform within itself. By maintaining separate inbred lines with different trait combinations rather than a single homogeneous population, the system preserves overall genetic diversity while achieving uniformity within each line. These segmented lines can then be strategically combined through cross-pollination.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent changes the genetic parameter from heterozygous to homozygous state through controlled self-pollination of inbred lines. This parameter change achieves genetic uniformity within each line while the collection of multiple lines with different homozygous genotypes maintains overall genetic diversity for the breeding program.

Inventive Principle:
Principle #35Parameter changes

3Adaptability or versatility

If cross-pollination is used to produce hybrid plants, then genetic variability and trait combination are improved, but uniformity in progeny decreases

Engineering Contradiction:
Improvetrait combinationVSAvoidprogeny uniformity
Core Design Contradiction:
Adaptability or versatilityVSStability of the object's composition

Solution Approach 1:

The patent changes the genetic parameter from heterozygous to homozygous state through multiple generations of self-pollination before hybridization. By starting with homozygous inbred parental lines, the F1 hybrid progeny receive identical alleles from each parent, resulting in uniform heterozygous genotypes across all offspring. This parameter change ensures both trait combination and progeny uniformity.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

Preliminary development of homozygous inbred parental lines is performed before cross-pollination. This preliminary action ensures that both parents have fixed, uniform genotypes, so when cross-pollination occurs, all F1 progeny receive the same combination of alleles, resulting in uniform hybrids with consistent trait expression.

Inventive Principle:
Principle #10Preliminary action

4Adaptability or versatility

If multiple breeding generations are conducted to combine desirable traits, then trait combination is improved, but breeding complexity and resource requirements increase

Engineering Contradiction:
Improvetrait combinationVSAvoidbreeding program complexity
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The breeding program is segmented into independent inbred line development programs, each focused on incorporating specific desirable traits. By dividing the overall breeding goal into separate line development projects, complexity is distributed and managed more efficiently. Each line can be developed in parallel with dedicated resources, and the segmented lines are then combined through systematic hybridization.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

Desirable traits are incorporated into inbred parental lines through preliminary breeding generations before the final hybridization step. This preliminary action consolidates multiple trait incorporation steps into the parental line development phase, so the final hybridization only requires a single cross to combine pre-developed trait combinations, reducing overall program complexity.

Inventive Principle:
Principle #10Preliminary action

Data Source

PatentUS12446517B2Plants and seeds of hybrid corn variety CH010365
Publication Date: 2025.10.21 MONSANTO TECHNOLOGY LLC

AI summary

According to the invention, there is provided seed and plants of the hybrid corn variety designated CH010365. The invention thus relates to the plants, seeds and tissue cultures of the variety CH010365, and to methods for producing a corn plant produced by crossing a corn plant of variety CH010365 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH010365.