Chamomile Hydrosol Camphor Extraction for Skin Regeneration

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Solution Overview

Problem

Current skin regeneration compositions lack effective ingredients that can induce cell proliferation, migration, and anti-aging activities, particularly in addressing skin elasticity and wrinkle formation, as existing compositions do not utilize chamomile hydrosol or camphor effectively.

Innovation Solution

A composition incorporating chamomile hydrosol extracted by vacuum distillation, which contains camphor as a main active ingredient, is developed to promote skin regeneration by activating PI3K/AKT and ERK signaling pathways, enhancing cell viability, and inhibiting elastase activity, thereby improving skin elasticity and reducing signs of aging.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If chamomile essential oil is used for skin treatment, then antibacterial and antioxidant efficacies are improved, but the composition does not provide sufficient cell proliferation and migration effects

Engineering Contradiction:

Improveantibacterial and antioxidant efficacyVSAvoidcell proliferation and migration effect

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The patent extracts camphor, the main active ingredient, from chamomile essential oil through vacuum distillation to create chamomile hydrosol. This extraction process isolates the specific component (camphor) responsible for the desired biological activities, separating it from other components of the essential oil that may not contribute to cell proliferation and migration.

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The patent utilizes vacuum distillation to change the physical and chemical parameters of chamomile extraction, producing hydrosol with different compositional characteristics compared to traditional essential oil extraction. This parameter change enables the preservation of camphor's beneficial effects while achieving enhanced cell proliferation and migration activities.

Inventive Principle:

Principle #35Parameter changes

2Productivity

If chamomile hydrosol is used to promote cell proliferation, then skin regeneration is improved, but the composition must be precisely formulated to avoid harmful effects

Engineering Contradiction:

Improvecell proliferation and migrationVSAvoidtoxicity and sensitivity

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent uses chamomile hydrosol as an intermediary medium that delivers camphor to target cells in a controlled and safe manner. The hydrosol formulation acts as a carrier that modulates the delivery of camphor, enabling therapeutic effects while minimizing potential harmful impacts through the natural buffering properties of the hydrosol matrix.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Productivity

If conventional distillation is used to extract chamomile, then extraction efficiency is improved, but the active ingredient camphor is not effectively preserved

Engineering Contradiction:

Improveextraction efficiencyVSAvoidcamphor preservation

Core Design Contradiction:

ProductivityVSReliability

Solution Approach 1:

The patent employs vacuum distillation that utilizes controlled phase transitions of water and camphor at reduced pressures. This phase transition approach allows for the selective separation and preservation of camphor in the hydrosol without degradation, maintaining its biological activity while achieving effective extraction.

Inventive Principle:

Principle #36Phase transitions

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The chamomile hydrosol composition effectively induces cell proliferation and migration, enhances skin elasticity, and exhibits anti-aging properties by attenuating elastase activity and increasing collagen expression, making it suitable for cosmetic, pharmaceutical, and food applications.

Implementation Method 1

chamomile hydrosol prepared by vacuum distillation

Methodology Applied

Scientific EffectVacuum distillation: Vacuum Distillation

Data Source

PatentUS9623062B2Anti-ageing activity of camphor in fibroblast cell line

Publication Date: 2017.04.18 IND ACADEMIC COOPERATION FOUND JEJU NAT UNIVERSTIY

AI summary

The present invention provides a composition for skin regeneration including chamomile hydrosol prepared by vacuum distillation as an active ingredient. The composition for skin regeneration including camphor or chamomile hydrosol prepared by vacuum distillation, which contains the camphor, exhibits to excellent skin regeneration ability to promote proliferation and migration of skin cells, and simultaneously include only components derived from natural herbal plants, and thus can be used in various forms such as medicine, quasi-drugs, cosmetics, and food materials without any of side effects.