Gastrointestinal Composition Using Activated Charcoal and Enzymes

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Solution Overview

Problem

Current treatments for gastrointestinal disorders such as dyspepsia, pyrosis, meteorism, and flatulence often have side effects and are not tolerated by all individuals, and existing pharmacological therapies do not effectively address the underlying issues of gastric emptying and intestinal gas accumulation.

Innovation Solution

A pharmaceutical composition comprising activated charcoal, Carum carvi extract, and papain, with optional α-galactosidase and β-galactosidase, which works synergistically to increase gastric emptying and reduce intestinal gas, thereby addressing the symptoms of dyspepsia, pyrosis, meteorism, and flatulence.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If conventional pharmacological therapies are used to treat gastrointestinal disorders, then the treatment covers a broad range of symptoms, but the therapies cause side effects and are not tolerated by all individuals

Engineering Contradiction:

Improvetreatment coverageVSAvoidside effects

Core Design Contradiction:

Adaptability or versatilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical composition parameters by using natural substances (activated charcoal, Carum carvi extract, papain, and optional galactosidases) instead of conventional pharmaceutical compounds. This parameter change maintains treatment versatility while eliminating the harmful side effects associated with synthetic drugs, as these natural components are better tolerated by the human body.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention creates a composite formulation combining multiple natural active ingredients that work synergistically. Activated charcoal adsorbs gas, Carum carvi extract provides carminative effects, papain aids protein digestion, and galactosidases break down complex carbohydrates. This composite approach broadens treatment coverage across multiple gastrointestinal symptoms while maintaining high tolerability.

Inventive Principle:

Principle #40Composite materials

2Reliability

If conventional treatments are used for gastrointestinal disorders, then they address symptoms superficially, but they do not effectively increase gastric emptying or reduce intestinal gas accumulation

Engineering Contradiction:

Improvesymptom reliefVSAvoidgastric emptying rate

Core Design Contradiction:

ReliabilityVSProductivity

Solution Approach 1:

The formulation performs preliminary actions to prevent gastrointestinal problems before they fully develop. Papain and galactosidases pre-digest proteins and complex carbohydrates in the stomach, preventing excessive gas formation during intestinal fermentation. Carum carvi extract prepares the gastrointestinal tract for efficient emptying, addressing the root causes rather than just symptoms.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent replaces conventional pharmacological mechanisms with natural physiological mechanisms. Instead of using prokinetic drugs that stimulate muscle contraction, the formulation uses papain and Carum carvi extract to naturally enhance gastric emptying through enzymatic digestion and carminative action. Similarly, instead of using anti-gas medications, activated charcoal physically adsorbs gas through surface adsorption.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

3Quantity of substance

If activated charcoal is used alone to reduce intestinal gas, then gas adsorption occurs, but gastric emptying is not improved and other digestive functions are not addressed

Engineering Contradiction:

Improveintestinal gas volumeVSAvoidgastric emptying

Core Design Contradiction:

Quantity of substanceVSProductivity

Solution Approach 1:

The invention merges activated charcoal's gas adsorption capability with Carum carvi extract's prokinetic effects, papain's proteolytic activity, and optional galactosidases' carbohydrate-digesting enzymes. This combination allows the single formulation to simultaneously reduce intestinal gas volume while improving gastric emptying rate and addressing multiple digestive functions, eliminating the need for multiple separate treatments.

Inventive Principle:

Principle #5Merging (Combining)

4Adaptability or versatility

If complex pharmaceutical compositions are used to treat multiple gastrointestinal symptoms, then broad coverage is achieved, but the composition complexity and potential for adverse reactions increase

Engineering Contradiction:

Improvemulti-symptom treatmentVSAvoidcomposition complexity

Core Design Contradiction:

Adaptability or versatilityVSDevice complexity

Solution Approach 1:

Each component in the formulation serves multiple functions: activated charcoal adsorbs gas and toxins while being inert and safe; Carum carvi extract provides carminative, prokinetic, and antispasmodic effects; papain aids protein digestion and reduces gas formation; and galactosidases break down complex carbohydrates. This multi-functionality allows a relatively simple four-component formulation to treat multiple gastrointestinal symptoms without increasing complexity or adverse reaction risk.

Inventive Principle:

Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively increases gastric emptying, reduces intestinal gas, and alleviates symptoms of dyspepsia, pyrosis, meteorism, and flatulence, offering a side-effect-free solution for gastrointestinal disorders by combining the adsorption of intestinal gases with prokinetic and enzymatic activities.

Implementation Method 1

Methodology Applied

Scientific EffectAdsorption: Adsorption

Implementation Method 2

A pharmaceutical composition comprising activated charcoal, Carum carvi extract, and papain

Methodology Applied

Scientific EffectEnzyme: Enzyme

Implementation Method 3

with optional α-galactosidase and β-galactosidase

Methodology Applied

Scientific EffectEnzyme: Enzyme

Data Source

PatentUS11590166B2Composition for the treatment of gastrointestinal disorders

Publication Date: 2023.02.28 NEILOS SRL

AI summary

The present invention relates to a pharmaceutical composition which contains activated charcoal, Carum carvi extract, papain and, optionally, α-galactosidase and β-galactosidase for the treatment of gastrointestinal disorders.