Charged Carrier for Removing Activated Leukocyte-Platelet Complexes
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Solution Overview
Problem
Current materials and technologies lack the capability to efficiently remove activated leukocyte-activated platelet complexes, which are involved in inflammatory diseases such as respiratory conditions, due to differences in protein expression, size, and bioactivity compared to individual leukocytes and platelets.
Innovation Solution
A water-insoluble carrier with bound charged functional groups and a specific extending length ratio of 4 to 7, center line mean roughness of 2 to 10 μm, and absolute charge amount of 0.3 to 3.0 mmol/g is used to effectively remove activated leukocyte-activated platelet complexes, utilizing polymers like polystyrene, polysulfone, and polyethersulfone, and incorporating amino groups for high efficiency.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional materials are used to remove leukocytes and platelets, then individual cells can be removed, but activated leukocyte-activated platelet complexes cannot be efficiently removed due to differences in size, protein expression, and bioactivity
Solution Approach 1:
The patent changes the surface parameters of the carrier by controlling the extending length ratio to 4-7 and center line mean roughness to 2-10 μm, which enables the carrier to effectively interact with and remove activated leukocyte-activated platelet complexes that have different size and surface properties compared to individual cells
Solution Approach 2:
The patent uses composite material structure combining water-insoluble carrier with charged functional groups (amino groups with absolute charge amount 0.3-3.0 mmol/g) to create a multifunctional surface that can simultaneously interact with various components of the activated leukocyte-activated platelet complex through electrostatic and other molecular interactions
2Reliability
If a water-insoluble carrier with charged functional groups is used, then removal efficiency of activated leukocyte-activated platelet complexes increases, but manufacturing precision requirements increase due to specific extending length ratio and roughness specifications
Solution Approach 1:
The patent defines specific parameter ranges for extending length ratio (4-7) and center line mean roughness (2-10 μm) that balance removal efficiency with manufacturability, allowing industrial production while maintaining therapeutic effectiveness
3Stability of the object's composition
If polymers like polystyrene, polysulfone, and polyethersulfone are used as carrier materials, then chemical stability and charge immobilization improve, but device complexity increases due to multiple polymer selection and functional group integration
Solution Approach 1:
The patent selects from a limited set of homogeneous polymer materials (polystyrene, polysulfone, polyethersulfone) with similar properties that can all provide the required chemical stability and charge immobilization, simplifying the overall material system while maintaining performance
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The material achieves high efficiency in removing activated leukocyte-activated platelet complexes, providing therapeutic benefits for respiratory diseases by using an extracorporeal circulation column, particularly effective in treating acute lung injury and acute respiratory distress syndrome (ARDS).
Implementation Method 1
a water-insoluble carrier to the surface of which carrier a compound(s) having a charged functional group(s) is(are) bound
Data Source
AI summary
An object of the present invention is to provide a material which can remove an activated leukocyte-activated platelet complex with high efficiency. The present invention provides a material for removing an activated leukocyte-activated platelet complex, the material being a water-insoluble carrier to the surface of which carrier a compound(s) having a charged functional group(s) is(are) bound, wherein an extending length ratio of the surface is 4 to 7.