Automated Chemiluminescence Analyzer Nested Module Layout
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Solution Overview
Problem
Current chemiluminescence immunoassay analyzers have complex structures, large footprints, and high costs, which hinder their use due to inefficiencies and high operational expenses.
Innovation Solution
A fully automatic chemiluminescence immunoassay analyzer with a simplified structure, reduced size, and lower production costs, featuring a sample and reagent receiving device, dispensing device, mixing device, incubation and luminescence detection device, magnetic separation cleaning device, and liquid path device, allowing for independent rotation of sample and reagent receiving mechanisms and efficient transfer of reaction vessels between components.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If current chemiluminescence immunoassay analyzers are used, then detection sensitivity and specificity are maintained, but device complexity and footprint increase
Solution Approach 1:
The patent combines multiple functional modules (sample receiving, reagent receiving, dispensing, mixing, incubation, magnetic separation, and luminescence detection) into a single integrated analyzer system. This merging approach maintains comprehensive detection capabilities while reducing overall device complexity compared to having separate independent modules for each function.
Solution Approach 2:
The analyzer is designed with multi-functional components that can perform multiple operations. For example, the reaction vessel serves as both the mixing container and the incubation chamber, and the magnetic separation module also handles cleaning functions. This universality reduces the total number of components needed while maintaining detection sensitivity.
2Measurement precision
If current chemiluminescence immunoassay analyzers are used, then detection capability is maintained, but footprint and production cost increase
Solution Approach 1:
The patent employs a nested arrangement where the reagent receiving mechanism is positioned inside the sample receiving mechanism, and other functional modules are arranged in a compact nested configuration. This nesting strategy significantly reduces the horizontal footprint of the analyzer while maintaining all necessary detection capabilities.
Solution Approach 2:
The design transitions from a horizontal spread-out layout to a vertical stacked arrangement, utilizing the vertical dimension to house multiple functional modules. This dimensional change allows the analyzer to maintain comprehensive detection capability while minimizing the horizontal footprint on the laboratory bench.
3Measurement precision
If current chemiluminescence immunoassay analyzers are used, then detection accuracy is maintained, but operational cost and maintenance complexity increase
Solution Approach 1:
The analyzer is divided into modular functional units (sample receiving module, reagent receiving module, dispensing module, mixing module, incubation module, magnetic separation module, and detection module) that can be manufactured independently and assembled. This segmentation reduces production complexity and cost while maintaining detection accuracy through standardized interfaces and quality control at each module level.
Solution Approach 2:
The design incorporates reusable components such as the magnetic separation beads and reaction vessels that can be recovered and reused across multiple tests. This reduces consumable costs and operational expenses while maintaining detection accuracy through consistent performance of recovered components.
4Reliability
If current chemiluminescence immunoassay analyzers are used, then detection reliability is maintained, but test throughput and efficiency decrease
Solution Approach 1:
The patent implements an automated continuous workflow where the reaction vessel is sequentially transferred through mixing, incubation, magnetic separation, and detection without manual intervention. This continuous automated operation maintains detection reliability through consistent standardized procedures while significantly increasing test throughput compared to manual or semi-automated systems.
Solution Approach 2:
The system performs preliminary actions such as pre-mixing reagents, pre-incubating samples, and pre-positioning reaction vessels in the automated workflow path before actual testing begins. This preliminary preparation ensures detection reliability is maintained while reducing the time required for each test cycle, thereby increasing overall productivity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The analyzer achieves a compact design, reduces operational costs, and enhances test efficiency by integrating multiple functions and optimizing the workflow, making it easier to operate and maintain.
Implementation Method 1
a magnetic separation cleaning device for separation cleaning an analyte and impurities in the reaction vessel
Implementation Method 2
Chemiluminescence immunoassay technology is a highly sensitive and highly specific analytical instrument that has developed rapidly in the world in the past decade
Data Source
AI summary
A fully automated chemilumiescence immunoassay analyzer, including a sample and reagent receiving device for receiving a sample and a reagent, a dispensing device for aspirating and discharging the sample and the reagent, a mixing device for mixing the sample and the reagent in a reaction vessel, an incubation and luminescence detection device for incubation and luminescence detection, a magnetic separation cleaning device for separation cleaning an analyte and impurities in the reaction vessel, a reaction vessel grasping device for transferring the reaction vessel, and a liquid path device. The fully automated chemiluminescence immunoassay analyzer has a simple structure and is convenient to operate, and also reduce the overall size such that the footprint thereof is small and the production cost is reduced, so that the analyzer is easy to achieve miniaturization, and is convenient for an operator to use.