Chewable Composition Using Non-Water Wetting Agent and Flowable Oil
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Solution Overview
Problem
Current methods for administering pharmaceutical agents to animals are often complex or inconvenient, and existing chewable compositions may not be stable, easily accepted, or effective in delivering active ingredients due to the use of high amounts of water and fillers like cellulose-based materials.
Innovation Solution
A chewable composition that uses a wetting agent other than water in combination with a non-miscible flowable oil, along with a high content of meat flavor and a non-starch disintegrant like croscarmellose sodium, to create a stable, easily manufactured, and shelf-stable product with reduced filler and water content, facilitating the delivery of pharmaceutical active ingredients.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If high amounts of water and cellulose-based fillers are used in chewable compositions, then the composition can be manufactured and have desired consistency, but the product becomes less stable and has reduced shelf-life
Solution Approach 1:
The patent changes the formulation parameters by replacing water with alternative liquid binders (such as glycerin, propylene glycol, or vegetable oils) and reducing cellulose-based filler content. This parameter change maintains manufacturability through extrusion processes while significantly improving shelf-stability and reducing microbial growth risks associated with high water content formulations.
Solution Approach 2:
The patent employs composite material strategies by combining multiple binder types (e.g., glycerin with vegetable oils, or PEG with starch) to achieve the desired consistency and manufacturability without relying on high water content. These composite binder systems provide both processing benefits and enhanced stability.
2Ease of manufacture
If high amounts of fillers are used to achieve desired consistency, then the composition can be manufactured, but the delivery of active ingredient is reduced and product acceptance by animals decreases
Solution Approach 1:
The patent reduces filler content by changing the binder system from water-based to alternative liquids that provide adequate consistency at lower filler levels. This allows higher proportions of active ingredient to be incorporated while maintaining manufacturable consistency through extrusion.
3Ease of manufacture
If water is used as the primary liquid ingredient, then the composition can be easily manufactured, but the shelf-life is reduced and stability is compromised
Solution Approach 1:
The patent fundamentally changes the liquid ingredient parameter from water to alternative binders such as glycerin, propylene glycol, or vegetable oils. These alternatives maintain ease of manufacture through extrusion processes while providing superior shelf-stability and resistance to microbial degradation.
Solution Approach 2:
The patent replaces perishable water-based formulations with more stable alternative liquid binders that extend product shelf-life without significantly increasing manufacturing complexity.
Data Source
AI summary
A chewable composition, comprising: - at least one pharmaceutically active ingredient component; - solid components including: - at least one flavor; - at least one disintegrant including at least one non-starch disintegrant; - flowable components including: - a flowable oil; - at least one wetting agent other than water.